摘要
对现阶段多种药物溶血实验方法进行了对比研究,并依据红细胞破坏量、红细胞内容物释放等进行分类,发现干化学法替代氰化高铁法、4-氨基安替比林法替代甲联苯胺法等进行溶血试验可提高结果的精确度,更加便利和高效。由此,为药物生物安全性评价提供参考方法和依据。
A comparative research is conducted on the performance of various methods of hemolysis test for drugs nowadays. It is classif- icated by the destruction of erythrocyte or the release of erythrocyte cell content. It is found that the substitutions of a dry chemistry method for cyanmethemoglobin and 4-amino antipyrine method for o-methyl benzidine method can be more accuracy and higher perform-ance for hemolysis test. This review will provide references for the biocompatibility of drugs.
作者
冷毅伦
刘建莉
徐佳奇
马佳凤
曾如梦
林恒秀
LENG Yilun LIU Jianli XU Jiaqi MA Jiafeng ZENG Rumeng LIN Hengxiu(Hainan Medical College,Institute of Clinical,Haikou,Hainan 511199, China The First Affiliated Hospital of Hainan Medical College,Hainan Trauma and Disaster Rescue Key Laboratory,Haikou,Hainan 571199,China)
出处
《安徽医药》
CAS
2017年第3期424-427,共4页
Anhui Medical and Pharmaceutical Journal
基金
海南省自然科学基金(514216)
海南省科技合作专项(KJHZ2015-05)
大学生创新创业训练计划项目(201511810016)
