摘要
牙周炎已成为成人失牙的首要原因,调查显示全球约有44%~57%和10%的成人患有中度和重度牙周炎。而冠状动脉粥样硬化性心脏病(CHD)是临床上死亡率较高的疾病之一,严重危害着人类健康,其主要病理学基础是动脉粥样硬化(AS)和在斑块破裂基础上形成的血栓。牙周炎和冠心病之间存在着一定的联系,牙周致病菌通过直接作用定植在冠状动脉;通过间接作用产生各种细胞因子、黏附分子,引起全身炎症状态、脂质异常和凝血状态;激活固有免疫系统,分别形成生物性炎症、化学性炎症、免疫性炎症,最终形成和加重动脉粥样硬化,继而形成冠心病。本文旨在对牙周炎与冠心病之间联系机制的研究进展作一综述。
Periodontitis has become the most leading cause of tooth loss in adults.The survey shows that about44%-57% and 10% of adults have moderate and severe periodontitis all over the world.Coronary heart disease（CHD）is one of the diseases with higher mortality rate,which has serious harm to human health.The main pathological basis of CHD is atherosclerosis（AS）and the thrombus which are formed due to the plaque rupture.There are some connections between periodontitis and CHD.Periodontal pathogens colonized in coronary artery and produced lots of cytokines and adhesion molecules which can cause systemic inflammation,abnormal lipid and coagulation status.They further activated innate immune system and then biological inflammation,chemical inflammation,immune inflammation formed.Ultimately,AS was formed and aggravated,followed by CHD.This paper aims to summarize newly research progress on the link mechanism between periodontitis and CHD.
出处
《口腔医学研究》
CAS
北大核心
2017年第4期455-458,共4页
Journal of Oral Science Research
基金
国家自然科学基金地区项目(编号:31560159/C0309)
国家自然科学基金地区项目(编号:31360124/C0309)
甘肃省科技支撑项目(编号:144WCGA167)
关键词
牙周炎
冠心病
动脉粥样硬化
炎性细胞因子
Periodontitis
Coronary heart disease
Atherosclerosis
Inflammatory cytokines
