摘要
研究琼岛染木树茎中蒽醌类成分及其抗菌活性。综合运用多种色谱技术对琼岛染木树茎的乙醇提取物进行分离纯化,通过核磁及质谱对所得单体化合物进行结构鉴定,并通过微量稀释法对化合物进行抗菌活性测试,结果表明,从琼岛染木树茎的乙醇提取物中分离得到12个蒽醌类化合物。经鉴定,分别为:(1)虎刺醇;(2)3-羟基-1-甲氧基-2-甲酯基蒽醌;(3)6-羟基-1-甲氧基-2-甲基蒽醌;(4)2-羟基-3-甲基蒽醌;(5)3-羟基-1,2-二甲氧基蒽醌;(6)2-羟基-1-甲氧基蒽醌;(7)1,3-二羟基-2-甲基蒽醌;(8)1,6-二羟基-2-甲基蒽醌;(9)1,3,6-三羟基-2-甲基蒽醌;(10)3-羟基-1-甲氧基-2-甲醚基蒽醌;(11)2-羟甲基-3-羟基蒽醌;(12)3-O-β-primeveroside。抗菌活性表明,大多蒽醌类化合物具有较好的抗菌活性。
To study the antibacterial anthraquinone derivatives from the stems ofSaprosma merrillii Lo. The compounds were isolated and purified by silica gel column, Sephadex LH-20 and Semi-Preparative HPLC. The structures of all compounds were elucidated on the basis of NMR and MS analysis. Antibacterial activi- ty of all compounds was determined by the conventional broth dilution assay. Twelve anthraquinone deriva- tives were isolated and elucidated as damnacanthol： （1） 3-hydroxy-l-methoxy-2-carbomethoxyan- thraquinone; （2） 6-hydroxy- 1-methoxy-2-methylanthraquinone; （3） 2-hydroxy-3-methylanthraquinone; （4） 3-hydroxy- l^2-dimethoxyanthraquinone; （5） 2-hydroxy- 1-methoxyanthraquinone; （6） 1,3-dihydrox- y-2-methylanthraquinone; （7） 1,6-dihydroxy-2-methylanthraquinone; （8） 1,3,6-trihydroxy-2-methylan- thraquinone; （9） 3-hydroxy-l-methoxy-2-methyl etheranthraquinone; （10） 2-hydroxymethyl-3-hydroxyan- thraquinone; （1 I） and 3-0-[3 -primeveroside; （12） All compounds were isolated from this plant for the first time. Many of these compounds showed antibacterial activities.
出处
《热带农业工程》
2016年第5期49-54,共6页
Tropical Agricultural Engineering
关键词
染木树属
琼岛染木树
蒽醌
抗菌活性
saprosma
Saprosma merrillii
anthraquinone
antibacterial activities
