摘要
目的探讨膝关节骨性关节炎(knee osteoarthritis,KOA)的较佳治疗方案。方法从双氯芬酸钠治疗组(A组)、正清风痛宁口服治疗组(B组)、正清风痛宁关节腔注射与片剂序贯疗法组(C组)各随机抽取60例病例,比较3组治疗前后疗效、不良反应等指标。结果 3组患者治疗后的Lequesne指数均较治疗前下降(P均<0.01);A组治疗后的Lequesne指数与B组差异无统计学意义(P>0.05);C组治疗后的Lequesne指数均低于A组与B组(P均<0.01)。A、B、C 3组治疗总有效率分别为73.3%、75.0%、93.3%,A组疗效与B组比较差异无统计学意义(P>0.05),C组疗效优于A组与B组(P均<0.01)。A、B、C 3组不良反应发生率分别为26.7%、10.0%、11.7%,A组不良反应发生率高于B组与C组(P均<0.05);B组与C组的不良反应发生率差异无统计学意义(P>0.05)。结论正清风痛宁关节腔注射与片剂序贯疗法治疗KOA疗效好,不良反应较少。
Objective To investigate the better treatments of knee osteoarthritis.Methods Randomly selected 60 case from each of the following groups：diclofenac sodium treatment group（A）,zhengqingfengtongning oral treatment group（B）,zhengqingfengtongning articular cavity injection with tablet sequential therapy group（C）.Comparative analysis of the curative effect before and after treament,effective rate and the incidence of adverse reactions between each group.Results The lequesne index of all the 3 groups dropped significantly before and after treament（P〈0.01）.Compared each group after treatment,A and B had no statistical difference（P〉0.05）,C was significantly lower than A and B（P〈0.01）.The total effective rate of A,B and C were 73.3%,75.0% and 93.3%,A and B had no statistical difference（P〉0.05）,C was better than A and B（P〈0.01）.The incidence of adverse reactions of A,B and C were 26.7%,10.0% and 11.7%;A higher than B and C（P〈0.05）,but B and C had no significant difference（P〉0.05）.Conclusion Zhengqingfengtongning articular cavity injection with tablet sequential therapy have good curative effect and less adverse in treatment of KOA,worthy of clinical recommendations.
出处
《中国卫生标准管理》
2017年第8期87-89,共3页
China Health Standard Management
