摘要
他克莫司体内过程个体差异大,治疗窗窄,给药剂量难以掌握。为保证其临床实践中安全、有效及合理应用,已有许多国家和地区发布了他克莫司用药的相关指南;但这些指南仅针对特定疾病和人群,具有一定的局限性。文中对相关指南进行解读和分析,并结合他克莫司药物基因组学与治疗药物监测的最新研究进展,归纳整理适合中国人群的他克莫司个体化用药方法,进一步完善他克莫司在临床上的合理使用。
Tacrolimus exhibits varied individual pharmacokinetic and a narrow therapeutic window, resulting in difficulties in personalized medication. In order to improve the safety of tacrolimus in clinical application and its efficiency and rationality in clinical practice, many countries and regions in the world have issued a number of guidelines for tacrolimus application. However, these guide- lines generally aim at particular disease and race, and have certain limitation. In this article, the guidelines were explicated and ana- lyzed in detail.Moreover, an individual tacrolimus medication recommendation for Chinese population was summarized based on the lat- est research of tacrolimus pharmacogenomics and therapeutic drug monitoring so as to provide assistance for the rational use of tacrolimus.
出处
《医学研究生学报》
CAS
北大核心
2017年第4期342-347,共6页
Journal of Medical Postgraduates
关键词
他克莫司
治疗药物监测
基因检测
用药指南
Tacrolimus
Therapeutic drug monitoring
Polymorphism
Dosing recommendations
