摘要
目的:探讨COPD急性加重期患者血清CRP和PCT含量与全身炎症反应程度的相关性。方法:收集2012年8月~2016年2月本院收治的COPD急性加重期患者68例作为观察组,另取同期在本院进行健康体检的正常人50例作为正常对照组。采用放射免疫法检测血清CRP、PCT含量;进一步根据CRP、PCT含量中位数对观察组进行分组,检测高含量组、低含量组患者的血清促炎因子、抗炎因子、应激激素含量。结果:观察组患者血清中CRP、PCT的含量显著高于正常对照组;观察组中CRP、PCT高含量组患者的血清促炎因子IL-1β、IL-6、IL-8含量高于CRP、PCT低含量组,抗炎因子IL-4、IL-13含量低于CRP、PCT低含量组患者,应激激素AngⅡ、ALD、Cor含量高于CRP、PCT低含量组患者。结论:COPD急性加重期患者血清CRP和PCT含量与机体炎症反应程度呈正相关关系,可以作为疾病早期诊断、治疗效果评估及预后判断的辅助手段。
Objective： To investigate the correlation of serum CRP and PCT levels with systemic inflammatory response in patients with acute exacerbation of COPD.Methods： A total of 68 patients with acute exacerbation of COPD treated in our hospital between August 2012 and February 2016 were collected as observation group and 50 normal subjects receiving physical examination in our hospital during the same period were selected as normal control group.Radioimmunoassay was used to determine serum CRP and PCT levels;the observation group was further grouped according to the median of CRP and PCT levels, and serum levels of pro-inflammatory factors, anti-inflammatory factors and stress hormones of high level group and low level group were detected.Results： Serum CRP and PCT levels of observation group were significantly higher than those of normal control group;serum pro-inflammatory factors IL-1β, IL-6 and IL-8 levels of high CRP and PCT level groups within observation group were higher than those of low CRP and PCT level groups, anti-inflammatory factors IL-4 and IL-13 levels were lower than those of low CRP and PCT groups, and stress hormones Ang Ⅱ, ALD and Cor levels were higher than those of low CRP and PCT level groups.Conclusions： Serum CRP and PCT levels in patients with acute exacerbation of COPD are positively correlated with the inflammatory response extent in the body, and can be used as the auxiliary means for early disease diagnosis, treatment effect evaluation and prognosis judgment.
出处
《海南医学院学报》
CAS
2017年第5期620-622,626,共4页
Journal of Hainan Medical University
基金
广东省深圳市科技计划项目(医疗卫生类)(201103361)~~
