摘要
目的 探讨氟伐他汀治疗老年急性心肌梗死对心室重构以及血清肿瘤坏死因子α（tumor necrosis factor alpha,TNF-α）水平的影响。方法 选取2014年10月~2016年10月建德市中西医结合医院收治的87例老年急性心肌梗死患者,随机分为对照组（42例）和观察组（45例）。对照组患者均给予阿司匹林、氯毗格雷等常规治疗,观察组患者在此基础上联合氟伐他汀治疗。比较2组治疗前后心功能指标变化情况,比较2组治疗有效率,观察治疗前后患者心功能以及血清TNF-α水平变化情况。结果 治疗后2组的左心室重量指数、左心室收缩膜容量指数、左心室舒张膜容量指数、左心室射血分数均得到不同程度的改善,但观察组均改善明显（P〈0.05）,对照组则无明显改善,观察组各项指标均显著优于对照组（P〈0.05）。观察组有效率为93.33%,显著高于对照组的78.57%（P〈0.05）。治疗后2组的血清TNF-α水平均得到明显改善,与治疗前比较显著下降（P〈0.05）,且治疗后的观察组TNF-α水平显著低于对照组（P〈0.05）。结论 对老年急性心肌梗死患者实施氟伐他汀可以更好地改善患者的心功能,改善患者体内的炎性因子水平,有效提高治疗效果,抑制心室重构。
Objective To investigate the effect of fluvastatin on ventricular remodeling and serum tumor necrosis factor alpha（TNF-α） level in erly patients with acute myocardial infarction. Methods 87 elderly patients with acute myocardial infarction were chosen in Jiande Hospital of egrated Traditional Chinese and Western Medicine from October 2014 to October 2016, were randomly divided into control group （42 cases） and ervation group（45 cases ） , the control group received aspirin, PI Gray chlorine and other conventional treatment, the observation group were given vastatinon the basis of the control group treatment. The changes of cardiac function and serum inflammatory factor TNF-α levels were observed before d after treatment. Results After the treatment, left ventricular weight index such asleft ventricular systolic volume index, left ventricular diastolic mbrane membrane volume index, left ventricular ejection fraction in the two groups were improved in different degree, but the observation group proved significantly（P 〈0. 05）. In the control group, there was no significant improvement ; and after treatment, the indexes of the observation group re significantly better than those of the control group（P 〈0. 05）. The effective rate in the observation groupwas 93. 33% , was significantly higher than control group（P 〈0. 05） . After treatment, the levels of serum TNF-α were significantly improved in the observation group, and the level of serum was nificantly decreased compared with before treatment （ P 〈 0. 05 ） , and the observation group after the treatment was obviously lower than the control oup（P 〈 0. 05 ）. Conclusion For elderly patients with acute myocardial infarction with fluvastatin can better improve the patienfs heart function, prove the body’s inflammatory level, effectively improve the treatment effect, inhibit ventricular remodeling.
出处
《中国生化药物杂志》
CAS
2017年第4期397-400,共4页
Chinese Journal of Biochemical Pharmaceutics
关键词
急性心肌梗死
老年患者
氟伐他汀
心室重构
血清炎性因子
acute myocardial infarction
elderly patients
fluvastatin
ventricular remodeling
serum inflammatory factors
