摘要
目的观察阿托伐他汀钙片联合依折麦布片治疗急性心肌梗死(AMI)的临床疗效。方法选取2014年2月—2016年9月河池市人民医院收治的AMI患者104例,根据治疗方法分为对照组与观察组,每组52例。在常规治疗基础上,对照组患者予以阿托伐他汀钙片强化治疗,观察组患者予以常规剂量阿托伐他汀钙片联合依折麦布片治疗;两组患者均连续治疗4周。比较两组患者治疗前后血脂指标、丙氨酸氨基转氨酶(ALT)水平、超敏C反应蛋白(hs-CRP)水平、心功能指标[心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)、左心室舒张末期内径(LVDd),左心室射血分数(LVEF)],并观察两组患者治疗期间不良反应发生情况。结果治疗前两组患者三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、ALT、hs-CRP水平比较,差异无统计学意义(P>0.05);治疗后观察组患者TG、TC、LDL-C、ALT、hs-CRP水平低于对照组,HDL-C水平高于对照组(P<0.05)。治疗前两组患者cTnI水平、CK-MB水平、LVDd、LVEF比较,差异无统计学意义(P>0.05);治疗后观察组患者cTnI、CK-MB水平低于对照组,LVDd小于对照组,LVEF高于对照组(P<0.05)。两组患者治疗期间未发生严重不良反应。结论与阿托伐他汀钙片强化治疗相比,常规剂量阿托伐他汀钙片联合依折麦布片治疗AMI的临床疗效确切,可有效改善患者血脂代谢和心功能,减轻患者炎性反应,且安全性较高。
Objective To observe the clinical effect of atorvastatin calcium tablets combined with ezetimibe on acute myocardial infarction（ AMI）. Methods A total of 104 patients with AMI were selected in the People＇s Hospital of Hechi from February 2014 to September 2016, and they were divided into control group and observation group according to therapeutic methods,each of 52 cases. Based on conventional treatment,patients of control group received atorvastatin calcium tablets for intensive treatment, while patients of observation group received routine dose atorvastatin calcium tablets combined with ezetimibe; both groups continuously treated for 4 weeks. Blood lipids index, ALT, hs-CRP, index of cardiac function（ including cTnI,CK-MB,LVDd and LVEF） were compared between the two groups before and after treatment,and incidence of adverse reactions was observed during the treatment. Results No statistically significant differences of TG,TC,HDL-C,LDL-C,ALT or hs-CRP was found between the two groups before treatment（ P〉0. 05）; after treatment,TG,TC,LDL-C,ALT and hs-CRP of observation group were statistically significantly lower than those of control group,while HDL-C of observation group was statistically significantly higher than that of control group（ P〈0. 05）. No statistically significant differences of cTnI,CK-MB,LVDd or LVEF was found between the two groups before treatment（ P〉0. 05）; after treatment,cTnI and CK-MB of observation group were statistically significantly lower than those of control group,LVDd of observation group was statistically significantly shorter than that of control group,while LVEF of observation group was statistically significantly higher than that of control group（ P〈0. 05）. No one of the two groups occurred any serious adverse reactions during the treatment. Conclusion Compared with atorvastatin calcium tables intensive treatment,atorvastatin calcium tablets combined with ezetimibe has certain clinical effect in treating AMI,can effectively adjust the blood lipi
出处
《实用心脑肺血管病杂志》
2017年第8期109-112,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
心肌梗死
阿托伐他汀钙片
依折麦布片
治疗结果
Myocardial infarction
Atorvastatin calcium tablets
Ezetimibe tablets
Treatment outcome
