摘要
目的:探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者的血清可溶性尿激酶型纤溶酶原激活物受体(soluble urokinase-type plasminogen activator receptor,su PAR)水平及其诊断AECOPD的临床价值。方法:纳入2012年4月至2015年10月就诊的66例AECOPD患者(AECOPD组),同时纳入47例稳定COPD患者(s COPD组)及38例健康者(健康对照组)。记录各组一般情况,检测血常规、肺功能及动脉血氧等指标,收集外周血检测血清su PAR、C反应蛋白(C-reactive protein,CRP)、降钙素原(procalcitonin,PCT)水平。分析su PAR与各项指标的相关性,ROC曲线检测其用于诊断AECOPD的价值。结果:AECOPD组su PAR水平[(3.96±1.61)ng·ml-1]显著高于s COPD组[(2.06±0.91)ng·ml-1]及健康对照组[(1.73±0.99)ng·ml-1],差异均有统计学意义(P<0.001);且GOLD呼吸功能分级越高,su PAR水平就越高。AECOPD组su PAR水平与CRP(R=0.617,P<0.001)、PCT(R=0.523,P<0.001)、WBC(R=0.683,P<0.001)及GOLD分期(R=0.443,P<0.001)呈正相关,与PO2(R=-0.614,P<0.001)、FEV1%(R=-0.483,P<0.001)呈负相关。su PAR单独诊断AECOPD的曲线下面积(AUC)为0.816,联合CRP及PCT的AUC为0.859。结论:su PAR在AECOPD患者中显著升高,其单独及联合CRP及PCT可作为AECOPD临床诊断的重要参考指标。
Objective To investigate the serum soluble urokinase-type plasminogen activator receptor （suPAR） level in patients with AECOPD and its clinical value for AECOPD diagnosis. Methods A total of 66 patients with AECOPD from April 2012 to October 2015 were enrolled, 47 patients with cstable COPD （sCOPD group） and 38 healthy people （control group） were enrolled as control. General situations were recorded, routine blood tests, pulmonary function and arterial blood oxygen were detected. The suPAR, C-reactive protein （CRP） and procalcitonin （PCT） levels were detected. The relationship between suPAR and clinical parameters was analyzed. The ROC curve was used to evaluate the diagnostic value of suPAR in AECOPD patients. Results SuPAR level in AECOPD group （3.96 ± 1.61 ng·ml^-1） was significantly higher than sCOPD （2.06 ± 0.91 ng·ml^-1） and control group （1.73 ± 0.99 ng·ml^-1） （P〈0.001）. SuPAR in AECOPD group was positively correlated with CRP （R=0.617, P〈0.001）, PCT （R=0.523, P〈0.001）, WBC （R=0.683, P〈0.001） and GOLD stage （R=0.443, P〈0.001） , and negatively correlated with PO2 （R=-0.614, P〈0.001）, FEV1% （R=-0.483, P〈0.001）. AUC of suPAR alone for AECOPD diagnosis was 0.816, and AUC of suPAR combined with CRP and PCT was 0.859. Conclusion Serum suPAR in AECOPD patients is significantly elevated, which can be used to improve the diagnosis of AECOPD with CRP and PCT.
出处
《现代医学》
2017年第1期33-37,共5页
Modern Medical Journal
关键词
慢性阻塞性肺病急性加重期
可溶性尿激酶型纤溶酶原激活物受体
C反应蛋白
降钙素原
诊断
acute exacerbation of chronic obstructive pulmonary disease
soluble urokinase-type plasminogen activator receptor
C- reactive protein
procalcitonin
diagnosis
