摘要
目的探讨可溶性尿激酶型纤溶酶原激活物受体（suPAR）与白细胞介素27（IL-27）对多发性骨髓瘤（MM）总体生存时间（OS）的预测效能。方法通过ELISA法检测41例初治MM患者（观察组）和40例健康体检者（对照组）血浆suPAR及IL-27的表达,并进行比较;随访MM患者的OS,分析suPAR及IL-27与OS的关系。结果观察组suPAR、IL-27水平为（23.30±5.25）ng/mL、（11.23±2.55）ng/L,对照组suPAR、IL-27水平为（14.99±4.97）ng/mL、（18.32±6.70）ng/L,两组比较差异均有统计学意义（P〈0.05）。suPAR与年龄、血红蛋白、清蛋白、血肌酐、乳酸脱氢酶、β2微球蛋白均无明显相关性,而IL-27只与血红蛋白呈正相关（P〈0.05）。随访时间15（7~40）个月,在OS〈15个月组与OS≥15个月组,suPAR、IL-27在两组中比较差异均无统计学意义（P〉0.05）。suPAR〈23ng/mL组与≥23ng/mL组OS比较差异无统计学意义（P〉0.05）,IL-27〈11ng/L组与≥11ng/L组OS比较差异亦无统计学意义（P〉0.05）。结论在初治MM中,suPAR表达上升而IL-27表达下降,未发现二者对OS有预测效能。
Objective To explore the prediction efficiency of serum urokinase plasminogen activation receptor（suPAR）and interleukin-27（IL-27）to the overall survival（OS）time in the patients with multiple myeloma（MM）.Methods The ELISA method was adopted to detect the plasma suPAR and IL-27 expressions in 41 newly diagnosed patients with MM（observation group）and 40 persons undergoing the physical examination.The detection results were compared between the two groups.OS of MM patients were followed up and its relation with suPAR and IL-27 was analyzed.Results The levels of suPAR and IL-27 in the observation group were（23.30±5.25）ng/mL and（11.23±2.55）ng/L,which in the control group were（14.99±4.97）ng/mL and（18.32±6.70）ng/L respectively,there were statistically significant differences between the two groups（P0.05）.suPAR had no significant correlation with age,hemoglobin,albumin,serum creatinie,lactate dehydrogenase andβ2 microglobulin（β2-MG）,while IL-27 had only positive correlation with hemoglobin（P0.05）.The follow-up time was 15（7-40）months,the levels of suPAR and IL-27 had no statistical difference between the OS15months group and the OS≥15months group（P0.05）.OS had no statistical difference between the suPAR23ng/mL group and the suPAR ≥23ng/mL group,so did OS between the IL-2711ng/L group and the IL-27 ≥11ng/L group（P0.05）.Conclusion The suPAR expression is elevated and the IL-27 expression is decreased in the newly diagnosed MM patients,their prediction efficiency to OS is not found.
出处
《重庆医学》
CAS
北大核心
2016年第6期760-762,共3页
Chongqing medicine
基金
广西壮族自治区卫生厅科研资助项目(Z-2012578)
