摘要
目的探讨人类免疫缺陷病毒(HIV)合并乙肝病毒(HBV)感染对妊娠结局的影响。方法选取广东省广州市第八人民医院2009年1月至2016年5月收治的HIV孕妇306例,其中HIV合并HBV感染孕妇64例(肝功能正常38例,肝功能异常26例),单纯HIV感染孕妇242例,所有孕妇采取安全分娩及人工喂养等综合干预措施,观察各组妊娠结局、新生儿情况。结果 HIV合并HBV感染中,肝功能异常组产后出血和胎膜早破的比例均为26.92%,明显高于肝功能正常组及单纯HIV感染组(产后出血:χ~2值分别为4.335、10.774,均P<0.05;胎膜早破:χ~2值分别为4.335、15.363,均P<0.05);HIV合并HBV感染中肝功能正常组与单纯HIV感染组早产、产后出血、妊娠期高血压疾病及胎膜早破比较差异无统计学意义(χ~2值分别为0.000、0.002、0.020、0.000,均P>0.05);HIV合并HBV感染中,肝功能异常组死胎和新生儿窒息的比例分别为15.38%和26.92%,明显高于肝功能正常组及单纯HIV感染组(χ~2值分别为11.363、11.570,均P<0.05);各组存活婴儿随访期间HIV及HBV感染情况比较差异无统计学意义(χ~2值分别为0.376、0.000,均P>0.05)。结论 HIV合并HBV感染中,肝功能异常对妊娠结局有较明显的影响,产前检测应重视孕期肝功能检测。
Objective To investigate the influence of human immunodefieiency virus （ HIV ） combined with hepatitis B virus （ HBV ） infection on pregnancy outcomes. Methods From January 2009 to May 2016, altogether 306 cases of pregnant women infected with HIV were selected, among whom 64 cases were complicated with HBV infection （ with 38 cases of normal liver function and 26 cases of abnormal liver function） and 242 cases were simple HIV infection. All pregnant women were treated with safe delivery and artificial feeding and other comprehensive intervention measures. Pregnancy outcomes and neonatal conditions of each group were observed. Results For HIV combined with HBV infection patients, ratios of both postpartum hemorrhage and premature rupture of fetal membranes in liver function abnormal group were 26.92% , which were significantly higher than those in normal liver function group and pure HIV infection group （ for postpartum hemorrhage： χ2 value was 4. 335 and 10. 774, respectively, both P 〈 0.05 ; for premature rupture of fetal membranes ：χ2 value was 4. 335 and 15. 363, respectively, both P 〈 0.05）. Differences in premature birth, postpartum hemorrhage, hypertensive disease of pregnancy and premature rupture of fetal membranes between normal liver function group in HIV complicated with HBV infection patients and pure HIV infection group were not statistically significant （χ2 value was 0. 000, 0. 002, 0. 020 and 0. 000, respectively, all P 〉 0.05 ）. Stillbirth and neonatal asphyxia rates in abnormal liver function group of HIV combined with HBV infection patients were 15.38% and 26.92%, respectively, which were significantly higher than those in normal liver function group and pure HIV infection group （χ2 value was 11. 363 and 11. 570, respectively, both P 〈 0.05 ）. Differences in survival infants＇ infection of HIV and HBV in all groups during follow-up period were not statistically significant （χ2 values was 0.376 and 0. 000, respectively, both P 〉 0.05 ）. Conclusion
出处
《中国妇幼健康研究》
2017年第3期303-305,共3页
Chinese Journal of Woman and Child Health Research
基金
广东省自筹经费类科技计划资助项目(粤科规財字〔2015〕110号)
关键词
乙型肝炎病毒
人类免疫缺陷病毒
妊娠结局
肝功能
新生儿
hepatitis B virus（HBV）
human immunodeficiency virus（HIV）
pregnancy outcomes
liver function
neonate
