摘要
目的寻找可以预测非前哨淋巴结(non-sentinel lymph nodes,nSLNs)转移的因素。方法回顾性分析1999年5月—2015年9月在同济大学附属同济医院进行乳腺癌前哨淋巴结(sentinel lymph nodes,SLNs)活检的病例,通过多因素分析判断哪些临床病理因素与nSLNs转移相关。结果共有162例患者进行了SLNs活检和腋窝清扫,多因素分析表明,原发肿瘤直径>2 cm(P=0.023)、SLNs转移灶直径>2 mm(P=0.016)和脉管受侵(P=0.001)是nSLNs转移的独立预测因素,患者具有的不良因素越多,则nSLNs发生转移的可能性越大。结论 nSLNs是否转移与原发肿瘤大小、SLNs转移灶最大径和脉管受侵有关,对原发肿瘤及其SLNs进行详细的病理学检查将有助于筛查出真正需要进行腋窝清扫的患者。
Objective To identify factors that can predict metastatic involvement of non-sentinel lymph nodes （nSLNs）. Methods We reviewed the records of all patients with invasive breast cancer who underwent sentinel lymph nodes （SLNs） biopsy at Affiliated Hospital of Tongji Hospital between May 1999 and September 2015. Multiple regression analysis was used to identify clinicopathologic factors in SLNs-positive patients that could predict metastatic involvement of nSLNs. Results A total of 162 patients had positive SLNs and underwent completion axillary lymph node dissection. Multiple regression analysis revealed that primary tumor 〉2 cm （P=0.023）, SLNs metastasis 〉2 ram （P=O.O 16）, and lymphovascular invasion （P=O.O01 ） were independent predictors of nSLNs metastasis. The more above variables a patient had, the higher likelihood of nSLNs metastasis was. Conclusion The likelihood of positive nSLNs correlates with primary tumor size, size of the largest SLNs metastasis, and presence of lymphovascular invasion. Detailed pathologic examination of the primary tumor and its SLNs metastases may increase precision in the selection of patients for further axillary surgery.
作者
张涛
施宝民
王洪
崔乃鹏
林锐
季堃
ZHANG Tao SHI Baomin WANG Hong CUI Naipeng LIN Rui JI Kun(Department of General Surgery, Tong]i Hospital, Tongji University School of Medicine, Shanghai 200065, China Department of Ontology Surgery,Affiliated Hospital of Hebei University, Baoding 031000, China)
出处
《外科研究与新技术》
2017年第1期1-4,共4页
Surgical Research and New Technique
关键词
腋窝清扫
乳腺癌
预测因素
前哨淋巴结
Axillary dissection
Breast cancer
Predictive factor
Sentinel lymph node
