摘要
目的通过比较黄体酮联合人绒毛膜促性素(hC G)与单纯黄体酮治疗先兆流产的疗效,探讨其对孕酮(P)、hC G和雌二醇(E_2)水平的影响。方法选取2015年1月-2016年1月在荆州市第三人民医院就诊的先兆流产患者526例,按入院顺序随机分为对照组(263例)和观察组(263例),对照组采用黄体酮治疗,观察组采用黄体酮联合hC G治疗,观察两组患者的不良反应和妊娠结局,检测两组患者孕8周、9~12周的血清P、hC G和E_2的水平。结果在孕8周时,观察组P、hC G、E_2水平比较,差异无统计学意义(P>0.05);而在孕9~12周,观察组的P水平为(124.75±21.98)ng/mg,对照组为(96.82±19.36)ng/mg,两组比较,差异有统计学意义(P<0.05);观察组的hC G水平为(66 914.75±689.32)mI U/ml,对照组为(1 364.63±231.69)mI U/ml,两组比较,差异有统计学意义(P<0.05);观察组的E_2水平为(914.01±89.62)pg/ml,对照组为(324.57±71.40)pg/ml,两组比较,差异有统计学意义(P<0.05)。治疗后观察组足月妊娠率为93.16%,对照组为75.29%,两组比较,差异有统计学意义(P<0.05)。观察组的新生儿畸形率为0.76%,对照组为4.94%,两组比较,差异有统计学意义(P<0.05);观察组不良反应发生率为0.76%,对照组为6.84%,两组比较,差异有统计学意义(P<0.05)。结论黄体酮联合hC G治疗先兆流产对患者P、hC G和E_2水平更显著,分娩结局良好,不良反应发生少。
Objective To explore the effect of progesterone combined with human chorionic gonadotrophin（ hC G） treatment on serum progesterone,hC G,and estradiol levels in patients with threatened abortion by comparing the curative effects of progesterone combined with hC G and single application of progesterone in treatment of threatened abortion. Methods A total of 526 patients with threatened abortion treated in the hospital from January 2015 to January 2016 were selected and divided into control group and observation group according to the sequence of hospitalization,263 patients in each group. The patients in control group were treated by progesterone,while the patients in observation group were treated by progesterone combined with hC G. The adverse reactions and pregnancy outcomes in the two groups were observed. The levels of serum progesterone,hC G,and estradiol during the eighth gestational week and the 9th-12 th gestational weeks in the two groups were detected. Results During the eighth gestational week,there was no statistically significant difference in the levels of serum progesterone,hC G,and estradiol between the two groups（ P〉0. 05）. During the 9th-12 th gestational weeks,the levels of serum progesterone in observation group and control group were（ 124. 75±21. 98） ng/mg and（ 96. 82±19. 36） ng/mg,respectively,there was statistically significant difference between the two groups（ P〈0. 05）; the levels of serum hC G in observation group and control group were（ 66 914. 75±689. 32） mI U/ml and（ 1 364. 63±231. 69） mI U/ml,respectively,there was statistically significant difference between the two groups（ P〈0. 05）; the levels of serum estradiol in observation group and control group were（ 914. 01±89. 62） pg/ml and（ 324. 57±71. 40） pg/ml,respectively,there was statistically significant difference between the two groups（ P〈0. 05）. After treatment,the full-term pregnancy rates in observation group and control group were 93. 16% and 75. 29%,respectively,there wa
出处
《中国妇幼保健》
CAS
2017年第7期1542-1544,共3页
Maternal and Child Health Care of China
关键词
黄体酮
绒毛膜促性素
先兆流产
雌二醇
Progesterone
Human chorionic gonadotrophin
Threatened abortion
Estradiol
