摘要
目的探讨异丙托溴铵联合丙酸倍氯米松雾化吸入治疗慢性阻塞性肺疾病(COPD)急性加重期的临床疗效。方法选取盐边县人民医院2014年12月—2015年6月收治的COPD急性加重期患者98例,根据治疗方法的不同分为对照组和观察组,各49例。患者入院后均给予常规基础治疗,对照组患者给予丙酸倍氯米松雾化吸入治疗,观察组患者在对照组基础上联合异丙托溴铵治疗,两组患者均持续治疗8周。比较两组患者临床疗效,治疗前后肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、残气量(RV)],咳喘、肺部哮鸣音、肺部啰音消失时间及不良反应发生情况。结果观察组患者临床疗效优于对照组(P<0.05)。治疗前,两组患者FVC、FEV1、RV比较,差异无统计学意义(P>0.05);治疗后,观察组患者FVC、FEV1、RV高于对照组(P<0.05)。观察组患者咳喘、肺部哮鸣音、肺部啰音消失时间短于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论异丙托溴铵联合丙酸倍氯米松雾化吸入治疗COPD急性加重期的临床疗效确切,可明显改善患者肺功能,促进疾病恢复,且安全可靠。
Objective To observe the clinical effect of ipratropium bromide combined with beclometasone dipropionate atomization inhalation in treating acute exacerbation of chronic obstructive pulmonary disease （COPD）. Methods A total of 98 cases of acute exacerbation of COPD patients were selected from December 2014 to June 2015 in People＇s Hospital of Yanbian County, which were divided into control group and observation group according to different treatments, 49 cases in each group. Both groups were given conventional therapy, control group was treated with beclometasone dipropionate atomization inhalation, observation group was treated with ipratropium bromide based on control group, both groups were treated for 8 weeks. The clinical effect, lung function indices （FVC, FEVI , RV） before and after treatment, disappeared time of cough and asthma, wheeze, lung tale, and the incidence of adverse reactions were compared between the two groups. Results The observation group of clinical effect was better than control group （ P 〈 0. 05 ）. Before treatment, no significant differences of FVC, FEV1 , RV was found between the two groups （ P 〉 0. 05 ） ; after treatment, the observation group of FVC, FEV1 , RV were higher than control group （ P 〈 0. 05 ）. The disappeared time of cough and asthma, wheeze, lung rale of observation group were shorter than control group （ P 〈 0. 05 ）. No significant difference of the incidence of adverse reactions was found between the two groups （P 〉 0.05 ）. Conclusion Ipratropium bromide combined with beclometasone dipropionate atomization inhalation have an exactly clinical effect in treating acute exacerbation of COPD, it can obviously improve the lung function, promote disease recovery, and with safety and reliable.
出处
《临床合理用药杂志》
2017年第6期1-2,7,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
肺疾病
慢性阻塞性
急性加重期
异丙托溴铵
丙酸倍氯米松
雾化吸入
Pulmonary disease, chronic obstructive
Acute exacerbation
Ipratropium bromide
Beclometasone dipropionate
Atomization inhalation
