摘要
目的了解北京市房山区健康人群白喉免疫水平,为传染病预防控制工作提供科学依据。方法采集房山区10个乡镇本市及外省健康人群血标本260份,采用酶联免疫吸附试验(ELISA)检测白喉IgG抗体。结果房山区抗体阳性率为64.62%,抗体几何平均滴度(GMT)为1.00 U/ml。不同性别间抗体阳性率比较,差异无统计学意义(χ~2=0.29,P=0.61)。不同年龄、不同免疫史抗体阳性率比较,差异有统计学意义(χ~2=76.26,P=0.00;χ~2=18.22,P=0.00),20岁以后抗体阳性率和GMT随年龄增长和免疫后时间延长而逐渐下降。结论预测房山区近期不会发生白喉流行,建议在大年龄组人群中开展白破疫苗加强免疫。
[Objective]To know the diphtheria antibody level among healthy population in Fangshan District of Beijing,provide scientific basis for infectious disease prevention and control. [Methods]Totally 260 serum samples were collected from the local and floating population in 10 towns of Fangshan District. The diphtheria Ig G antibody was determined with ELISA. [Results]The diphtheria antibody positive rate was 64.62%,and the geometric mean titer（GMT） was 1.00 IU/ml. There was no statistically significant difference in antibody positive rate between gender groups（χ^2=0.29,P=0.61）. The differences in antibody positive rate were statistically significant among groups in different age,immunization history（χ^2 = 76. 26,P = 0. 00;χ^2 = 18. 22,P = 0. 00）.A decreasing trend of antibody positive rate and GMT was observed with increasing age and years after immunization in healthy people above 20 years old.[Conclusion]It is predicted that diphtheria outbreak would not occur recently in Fangshan District. It is suggested that the booster immunization of Diphtheria-Tetanus vaccine should be carried out in large age group.
出处
《职业与健康》
CAS
2017年第3期389-391,共3页
Occupation and Health
关键词
健康人群
抗体水平
白喉
Healthy population
Antibody level
Diphtheria
