摘要
目的观察前列地尔对急性ST段抬高型心肌梗死(STEMI)患者行急诊经皮冠状动脉介入治疗(PCI)术后心功能的影响。方法选取2015年4月—2016年5月在聊城市第二人民医院心内科行急诊PCI的急性STEMI患者100例,采用随机数字表法将其分为对照组和试验组,各50例。对照组给予常规水化治疗;观察组在常规水化治疗的基础上于术前30min开始给予前列地尔10μg+0.9%氯化钠溶液100ml静脉滴注,1次/d,连续7d。两组患者均于术后6h、12h及24h测定血清肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)水平,并于术后24h及7d测定N-末端脑钠肽前体(NT-pro BNP)、每搏输出量(SV)、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)。结果术后6h、12h以及24h,试验组CK和CK-MB水平均低于对照组,差异有统计学意义(P<0.05)。术后24h,两组NT-pro BNP、SV、LVEDD、LVEF比较,差异均无统计学意义(P>0.05)。术后7d,试验组NT-pro BNP、LVEDD均低于对照组,SV、LVEF高于对照组,差异均有统计学意义(P<0.05)。结论前列地尔可明显改善急性STEMI患者PCI术后的心功能。
Objective To investigate the effect of alprostadil on cardiac function in patients with acute ST-segment elevation myocardial infarction( STEMI) undergoing emergent percutaneous coronary intervention( PCI). Methods From April 2015 to May 2016,100 acute STEMI patients undergoing emergency PCI admitted to Department of Cardiology,the Second People's Hospital of Liaocheng were randomly divided into control group and experiment group,each of 50 cases. Control group was treated with conventional hydration therapy,while experiment group was daily given with 10μg alprostadil in 0. 9% sodium chloride injection 100 ml before conventional therapy for 7days. Serum levels of CK,CK-MB were detected after 6,12 and 24 hours of emergency PCI; plasma NT-pro BNP level,SV,LVEFD,LVEF were examined after 24 hours and 7days of emergency PCI. Results Serum levels of CK,CK-MB in experiment group were lower than those in control group after 12 and 24 hours of emergency PCI( P < 0. 05). No significant differences was found of plasma NT-pro BNP level, SV and LVEDD, LVEF between the two groups after 24 hours of emergency PCI( P > 0. 05); while plasma NT-pro BNP level and LVEDD in experiment group were lower than those in control group,SV and LVEF were higher than those in control group after 7days of emergency PCI( P < 0. 05). Conclusion Alprostadil can improve the cardiac function in patients with acute STEMI undergoing emergent PCI.
出处
《实用心脑肺血管病杂志》
2016年第B12期24-27,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
心肌梗死
经皮冠状动脉介入术
前列地尔
心功能
Myocardial infarction
Percutaneous coronary intervention
Alprostadil
Cardiac function
