摘要
目的 观察前列地尔脂微球载体制剂对冠状动脉搭桥术后患者心肺功能的影响.方法 选取我院60例冠状动脉粥样硬化性心脏病（简称冠心病）患者,随机分为观察组和对照组,每组30例,两组患者术后均给予抗炎、营养心肌及机械通气等基础治疗,观察组术后静脉缓慢滴注稀释至30 ml生理盐水的前列地尔10μg,3次/天,共2d.检测两组患者术后0.5、6.0、12.0h动脉血氧分压（PaO2）及氧合指数（PaO2/FiO2）的变化,应用右心漂浮导管检测两组患者术后48h右心室射血分数（RVEF）、肺循环阻力（PVRI）的变化.结果 给药前（术后0.5 h）：观察组PaO2为（82.3±8.4） mmHg（1 mmHg =0.133 kPa）与对照组的（83.1±8.5） mmHg,观察组（PaO2/FiO2）为（212.8 ±10.4） mmHg,与对照组（214.3±10.7） mmHg比较,差异无统计学意义（P＞0.05）;给药后（术后6.0、12.0 h）：观察组PaO2为（96.0±9.8）、（108.0±10.6） mmHg,与对照组（84.3±6.1）、（86.7 ±7.3） mmHg比较,观察组（PaO2/FiO2）为（248.6±18.9）、（280.9±34.8）mmHg与对照组（220.5±16.1）、（245.9±28.2） mmHg比较,差异有统计学意义（P＜0.01）;术后48.0 h：观察组RVEF（0.53±0.05）与对照组（0.46±0.04）比较,观察组PVRI[（203±28） ml]与对照组[（235±33） ml]比较有显著改善（P＜0.05）.结论 前列地尔脂微球载体制剂可提高冠状动脉搭桥术后患者PaO2及PaO2/FiO2,改善患者心功能,提高患者氧合代谢,有助于冠状动脉搭桥术患者术后心肺功能的恢复.
Objective To investigate the effect of alprostadil on the cardio-pulmonary function of the patients after coronary artery bypass graft （CABG） by using Liposome prostaglandin.Methods Sixty cases of CAD were evenly divided into two groups：observation group and control group.Both groups were given the basic treatments such as anti-inflammation,mechanical ventilation,etc.Liposome prostaglandin was intravenously injected after surgery in control group,10 μg,thrice every day for 2 days.The changes of PaO2,and PaO2/FiO2 were examined at 0.5,6.0,and 12.0 h after surgery.The changes in RVEF and PVRI at 48.0 h after surgery were measured by using the right cardiac catheterization techniques.Results Before alprostadil administration and at 0.5 h after surgery,the PaO2 value was （82.3 ± 8.4） mmHg （1 mmHg=0.133 kPa） in observation group and （83.1 ±8.5） mmHg in control group,and the PaO2/FiO2 value was （212.8 ± 10.4） mmHg in observation group and （214.3 ± 10.7） mmHg in control group （P 〉0.05）.After alprostadil administration and at 6.0 and 12.0 h after surgery,the PaO2 value was （96.0±9.8） and （108.0 ± 10.6） mmHg in observation group and （84.3 ±6.1） and （86.7 ±7.3） mmHgin control group,and the PaO2/FiO2 value was （248.6 ± 18.9） and （280.9 ±34.8） mmHg in observation group and （220.5 ± 16.1） and （245.9 ±28.2） mmHg in control group,respectively （P 〈0.01）.At 48.0 h after surgery,RVEF in observation and control groups was （0.53 ±0.05） and （0.46 ± 0.04）,and PVRI was （203 ±28） and （235 ± 33） mL,respectively （P 〈0.05）.Conclusion Patients after CABG that were given liposome prostaglandin can get improvement in PaO2,PaO2/FiO2,RVEF and PVRI.Liposome prostaglandin administration also contributes to the recovery of postoperative cardiopulmonary function.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2014年第2期435-437,共3页
Chinese Journal of Experimental Surgery
关键词
前列地尔
冠状动脉搭桥术
心肺功能
Liposome prostaglandin
Coronary artery bypass graft
Cardio-pulmonary function
