摘要
肠道病毒71型(enterovirus type 71,EV-A71)感染常引起婴幼儿手足口病(hand,foot,and mouth disease,HFMD),严重者可伴有中枢神经系统并发症。近年来,EV-A71引起的手足口病已成为我国以及亚太地区迫切需要解决的公共卫生问题。目前,EV-A71的致病机制并不清楚,但逃逸宿主免疫应答被认为是其重要的致病机理之一。现主要就EV-A71逃逸宿主固有免疫的分子机制做一综述,概述近年来有关EV-A71如何利用其自身编码的2A pro、3C pro等非结构蛋白,影响宿主对病毒核酸的识别、IFN诱发生成及IFN信号通路的激活,从而逃逸宿主固有免疫的主要进展情况,并对抗病毒感染免疫治疗策略作简略讨论。
Enterovirus 71 （EV-A71） is a major etiological agent for outbreaks of hand, foot, and mouth disease （HFMD） in young children and infants. Infection with EV-A71 also results in severe neurological diseases. Recently, HFMD caused by EV-A71 has been the public health problem that needs great efforts in our country and other Asia-Pacific regions. However, the pathogenesis of EV-A71 infection has been unknown. Evasion of host innate immunity elicited by the virus has been considered to be the most important factor that contributes to the pathogenesis of EV-A71 infection. In this review, we summarized that EV-A71 evades host innate immunity and its molecular mechanisms, including the pathways by which the host recognizes virus infection, and the virus how to inhibit the production of host IFNs and block IFNs signaling. We also discussed the strategies for antiviral treatments based on the molecular mechanism of the virus evading host immunity.
出处
《生命科学》
CSCD
2017年第2期179-188,共10页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(31570516)
传染病重大专项基金项目(2012ZX10004503003)
