摘要
microRNA(miRNA)可参与转录后基因表达的调控,在调控HBV转录、复制中发挥着关键性作用。总结了肝细胞内具有抗HBV作用的miRNA及4种调控机制,HBV通过HBx及自身编码miRNA等影响肝细胞内源性miRNA表达,促进复制的机制。分析表明,肝细胞内源性miRNA与HBV交互作用构成一个复杂的调控网络,相互竞争调控的结果,决定了HBV转录的活性及疾病发展的趋势。深入研究肝细胞内源性miRNA与HBV交互作用影响HBV转录的机制,对探索新的抗HBV方法具有重要的意义。
MicroRNAs（ miRNAs） may be involved in the regulation of gene expression after transcription and play important roles in regulating hepatitis B virus（ HBV） transcription and replication. This article summarizes the miRNAs with an anti- HBV effect in hepatocytes and4 regulatory mechanisms,as well as the mechanisms through which HBV affects the expression of endogenous miRNAs in hepatocytes via HBx and self- coding miRNAs and promotes replication. The analyses show that the interaction between endogenous miRNAs and HBV in hepatocytes forms a complex regulatory network,competes for the results of regulation,and determines the activity of HBV transcription and the trend of disease progression. In- depth studies on the mechanisms of the influence of interaction between endogenous miRNA and HBV in hepatocytes on HBV transcription have great significance in exploring new anti- HBV methods.
出处
《临床肝胆病杂志》
CAS
2016年第11期2186-2190,共5页
Journal of Clinical Hepatology
基金
国家自然科学基金青年科学基金(81303066)
广西自然科学基金青年基金(2013GXNSFBA019154)
广西教育厅课题(2013YB121)
