摘要
目的:观察养心汤联用喹硫平对首发精神分裂症患者主观舒适度的影响。方法:48例患者随机服用养心汤联用喹硫平(治疗组)或者单用喹硫平(对照组),在入组时、第4、8周末采用阳性与阴性症状量表、不良反应症状量表评分,患者自评主观舒适度量表评价疗效。结果:两组患者精神症状均减轻(P<0.05或0.01)。治疗组口干、便秘、恶心等不良反应的发生率低于对照组(P<0.05),治疗组第4、8周末患者的主观舒适度均优于对照组(P<0.01)。结论:养心汤联用喹硫平治疗精神分裂症能有效控制精神症状,减少不良反应,提高患者主观舒适度。
Objective： To investigate the effect of Yangxin Decoction combined with Quetiapine on subjective well-being of schizophrenic patients. Methods： The 48 patients were randomly taken Yangxin Decoction combined quetiapine or quetiapinealone. At the beginning of the study and the end of week 4 and week 8, Subjective well-being under neuroleptic treatment scale will be evaluated by patients themselves, and Positive and negative syndrome scale and Treatment emergent symptoms scale will be evaluated by psychiatrists. Results： Two groups of patients mental symptoms were significantly reduced （P〈0.05 or 0.01）. The incidence of adverse reactions such as dry mouth, constipation, nausea and so on in the treatment group was lower than the control group （P〈 0.05）. And the subjective well-being of treatment group was better than the control group at the end of week 4 and week 8 （P〈0.01）. Conclusion： The Yangxin Decoction combined quctiapine treatment can effectively control the mental symptoms of schizophrenia, induce side effects and improve subjective well-being.
出处
《中医药导报》
2017年第6期80-82,共3页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
2015年度武汉市临床医学科研项目(中医药及中西医结合类)(WZ15Z05)
项目名称:养心汤改善精神分裂症患者主观舒适度临床研究
关键词
精神分裂症
养心汤
喹硫平
主观舒适度
schizophrenia
Yangxin decoction
quetiapine
subjective well-being
