摘要
目的探讨疏肝解郁胶囊联合阿立哌唑治疗精神分裂症的疗效及对血清神经元特异性烯醇化酶(NSE)、S100β钙结合蛋白(S100β)及脑源性神经营养因子(BDNF)水平的影响。方法选择医院2015年1月至2017年12月收治的精神分裂症患者97例,随机分为对照组(48例)和治疗组(49例)。对照组患者给予阿立哌唑治疗,治疗组患者加用疏肝解郁胶囊治疗,两组均连续治疗2个月。结果治疗组总有效率为95. 92%,明显高于对照组的75. 00%(χ~2=8. 591,P=0. 003 <0. 01);治疗后,两组患者匹兹堡睡眠质量指数(PSQI)及简明精神病评定量表(BPRS)评分均明显降低(P <0. 05),且治疗组明显低于对照组(P <0. 05);治疗后,两组患者血清S100β及NSE水平均明显降低,血清BDNF水平明显升高,且治疗组变化均优于对照组(P <0. 05);两组治疗过程中的不良反应发生率相当(10. 42%比12. 24%,χ2=0. 081,P=0. 777> 0. 05)。结论疏肝解郁胶囊联合阿立哌唑治疗精神分裂症临床疗效显著,能提高睡眠质量和精神状态,改善血清NSE,S100β,BDNF水平,且安全性较好,值得临床推广。
Objective To investigate the clinical efficacy of Shugan Jieyu Capsules combined with aripiprazole in the treatment of schizophrenia and its effect on the levels of serum neuron specific enolase( NSE),S100β calcium binding protein( S100β) and brain-derived neurotrophic factor( BDNF). Methods Totally 97 patients with schizophrenia admitted to our hospital from January 2015 to December 2017 were selected and randomly divided into the control group( 48 cases) and the treatment group( 49 cases). The control group was treated with aripiprazole,while the treatment group was treated with Shugan Jieyu Capsules combined with aripiprazole. The two groups were treated for 2 months. Results The total effective rate of the treatment group was 95. 92%,which was significantly higher than 75. 00% of the control group( χ^2 = 8. 591,P = 0. 003 < 0. 01). After treatment,the scores of PSQI and BPRS in the two groups were significantly decreased( P < 0. 05),and those in the treatment group were significantly lower than those in the control group( P < 0. 05). After treatment,the levels of serum S100β and NSE in the two groups were significantly decreased,while the levels of serum BDNF in the two groups were significantly increased,and the change in the treatment group was better than that in the control group( P < 0. 05). The incidence rate of adverse reactions in the two groups was similar( 10. 42% vs. 12. 24%,χ^2 = 0. 081,P =0. 777 > 0. 05). Conclusion Shugan Jieyu Capsules combined with aripiprazole in the treatment of schizophrenia have significant clinical effect and safety,they can improve sleep quality and mental state,improve the levels of serum NSE,S100β and BDNF,which are worthy of clinical promotion.
作者
王彬
杨开波
刘光美
Wang Bin;Yang Kaibo;Liu Guangmei(The Third People's Hospital of Parnhihua,Parnhihua,Sichuan,China 617061)
出处
《中国药业》
CAS
2018年第24期46-48,共3页
China Pharmaceuticals
基金
2016年四川省卫生和计划生育委员会科研课题[16PJ224]
