摘要
目的调查维持性腹膜透析及血液透析患者丙肝感染情况,并探讨血液透析患者丙肝感染的危险因素。方法回顾性分析2013年-2016年因终末期肾病在医院规律行透析治疗的患者208例的临床资料,将其中接受维持性腹膜透析的83例患者分为A组,将接受维持性血液透析的125例患者分为B组;比较两组患者感染率,并分析其危险因素。结果 A组丙肝感染率2.41%,B组丙肝感染率13.60%,A组丙肝感染率显著低于B组(P<0.05);多因素logistic回归分析结果显示,透析时间、合并症、蛋白摄入量、C-反应蛋白水平和白蛋白水平是维持性血液透析患者丙肝感染的独立危险因素(P<0.05)。结论与维持性腹膜透析相比,血液透析丙肝感染的风险更高;临床应加强透析管理,积极处理患者的合并症,改善患者的营养状态和微炎症状态,以降低丙肝感染率。
OBJECTIVE To investigate the peritoneal dialysis and hemodialysis in patients with hepatitis C virus （HCV） infection and to explore the risk factors of HCV infection in hemodialysis patients. METHODS The clinical data of 208 patients with end-stage renal disease in our hospital from 2013 to 2016 were analyzed retrospectively. A total of 83 patients who received maintenance peritoneal dialysis were divided into A group, and 125 patients with maintenance hemodialysis were divided into B group. The infection rates between the two groups were com- pared, and the risk factors were analyzed. RESULTS The HCV infection rates of group A and group B were was 2.41% and 13.60%, and the HCV infection rate of group A was significantly lower than that of group B （P〈0. 05）. Multivariate logistic regression analysis showed that the duration of dialysis, complications, protein in- take, the level of C reactive protein and albumin levels in dialysis patients were independent risk factors for HCV infection in maintenance hemodialysis patients （P〈0.05）. CONCLUSION Compared with maintenance peritoneal dialysis, hemodialysis dialysis had higher risk of HCV infection. It should strengthen the clinical management of dialysis, actively deal with the complications, and improve the patients nutritional status and inflammation, so as to reduce the incidence of HCV infection.
作者
华银玲
郭丽斌
时祥音
罗杉
陈红
HUA Yin-ling GUO Li-bin SHI Xiang-yin LUO Shan CHEN Hong(Nanyang Central Hospital, Zhengzhou University, Nanyang, Henan 473009, Chin)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第7期1497-1499,1503,共4页
Chinese Journal of Nosocomiology
基金
河南省医学科技攻关计划项目(201402H103)
关键词
腹膜透析
血液透析
丙肝
危险因素
Peritoneal dialysis
Hemodialysis
Hepatitis C
Risk factors
