摘要
腺苷酸活化蛋白激酶(AMP-activated Protein Kinase,AMPK)在调节细胞和全身代谢中发挥着重要作用,是研究治疗2型糖尿病药物的关键靶点。本文介绍了AMPK的结构及调节方式,并通过检索文献,对通过调节AMPK及其相关信号通路干预2型糖尿病的中药有效成分进行归纳总结。
The AMP-activated protein kinase （AMPK） is a key senor in cellular and systematic metabolism, and has become a key target in research of anti-diabetic drugs. This article is to introduce the structure and regulation mechanism of the AMPK. By literature searching, it is to summarize research progress on traditional Chinese medicine in the treatment of type 2 diabetes based on the AMP-activated protein kinase and related signaling pathway.
出处
《世界中医药》
CAS
2016年第11期2472-2475,共4页
World Chinese Medicine
基金
2015年陕西省自然科学基金面上项目(编号:2015JM8447)--二甲双胍与细胞毒药物脂质体对肿瘤干细胞引起肿瘤复发和转移研究
关键词
腺苷酸活化蛋白激酶
AMPK信号通路
2型糖尿病
中药
AMP-activated protein kinasc
AMPK signaling patllway
Type 2 diabetes
Chinese Materia Medica
