摘要
目的：探讨结肠癌肝转移的相关危险因素。方法：采用单因素分析及多因素Logistic逐步回归分析的方法对1997年1月-2013年12月期间我院收治的934例结肠癌患者的临床资料进行回顾性分析,探讨与结肠癌肝转移相关的危险因素。结果：单因素分析结果显示：肝转移组伴发合并症、发生腹腔种植、淋巴结转移、肿瘤浸润、肿瘤分化程度及血清CEA水平等因素与无肝转移组相比,差异有统计学意义（P均〈0.01）。多因素Logistic逐步回归分析结果显示：浸润深度深（OR=5.367,95%CI=2.451~11.755）、发生腹腔种植（OR=5.778,95%CI=1.963~17.009）、发生淋巴结转移（OR=5.178,95%CI=3.963~18.009）、分化程度高（OR=4.962,95%CI=2.958~16.016）、无合并症（OR=1.896,95%CI=1.853~14.617）、血清CEA水平高（OR=1.076,95%CI=1.489~13.817）等六项因素和结肠癌肝转移的发生密切相关,为结肠癌肝转移的独立危险因素。结论：是否伴发合并症、腹腔种植、淋巴结转移、肿瘤浸润、肿瘤分化程度及血清CEA水平等因素和结肠癌肝转移密切相关,且为结肠癌肝转移的主要独立危险因素。
ObjectiVe To explore the related risk factors of hepatic metastasis in patients with colon cancer. Methods From January 1997 to December 2013, the clinical data of 934 patients with colon cancer in our hospital were retrospectively analyzed by single factor and multiple factor Logistic regression, analysis, so as to explore the related risk factors of hepatic metastasis. Results The results of single factor analysis showed that the complications, celiac planting, lymph node metastasis, tumor invasion, tumor differentiation degree and serum CEA level were significantly different between patients with and without hepatic metastasis（ P〈0.01 ）. The results of multiple factor Logistic regression analysis demonstrated that six factors including deeply infiltration （ OR= 5. 367, 95%CI = 2.451 - 11,755）, celiac planting （ OR = 5.778, 95%CI =1.963- 17. 009）, lymph node metastasis （ OR= 5.178, 95%CI = 3.963 - 18.009）, high differentiation degree （ OR = 4.962, 95% CI=2.958-16.016）, no complications （OR= 1：896, 95%CI= 1.853- 14.617）and serum high CEA level （OR= 1.076, 95%CI= 1.489- 13.817） were closely related to the incidence of hepatic metastasis in patients with colon cancer. And they were independent risk factors. Conclu-si0n The factors such as complications, celiac planting, lymph node metastasis, tumor invasion, tumor differentiation degree and level of serum CEA are closely related to hepatic metastasis of colon cancer. The related factors including deeply infiltration,celiac planting , the lymph node metastasis, high degree of differentiation, no complications and high serum CEA level are the major independent risk factors for liver metastasis of colon cancer.
出处
《湖北医药学院学报》
CAS
2016年第6期570-573,共4页
Journal of Hubei University of Medicine
关键词
结肠癌
肝转移
危险因素
Colon cancer
Hepatic metastasis
Risk factor
