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正天丸联合川芎清脑颗粒治疗儿童偏头痛的疗效评价及机理研究 被引量:8

Clinical Effect and Mechanism of Zhengtian Pill Combined with Chuanxiong Qingnao Granules for Children Migraine
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摘要 目的:观察研究正天丸联合川芎清脑颗粒治疗儿童偏头痛的疗效及机理,为促进儿童偏头痛的康复提供科学依据。方法:选取2013年10月—2015年10月于医院儿童神经内科确诊的106例偏头痛患儿。随机分为实验组和对照组,每组各53例。对照组给予正天丸服用,实验组在对照组的基础上联用川芎清脑颗粒。观察两组的临床疗效及治疗前后TCD的变化情况。结果:研究结果显示,实验组的总有效率显著高于对照组,差异有统计学意义(P=0.026)。治疗前,两组患儿之间的MCA、ACA、PCA、BA、VA的血流速度无统计学差异(P>0.05)。治疗后,两组患儿的MCA、ACA、PCA、BA、VA血流速度均较治疗前降低(P<0.05)。且实验组的各项指标均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患儿之间的头痛程度、头痛持续时间、头痛次数无统计学差异(P>0.05)。治疗后,两组患儿的头痛程度、头痛持续时间、头痛次数均较治疗前降低(P<0.05)。且实验组的各项指标均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患儿之间的β-EP、ET、5-HT及NO比较无统计学差异(P>0.05)。治疗后,两组患儿的β-EP、ET、5-HT及NO均较治疗前有所变化(P<0.05)。且实验组β-EP、ET、5-HT及NO各项指标均变化小于对照组,差异有统计学意义(P<0.05)。结论:正天丸联合川芎清脑颗粒可针对儿童偏头痛风、瘀、湿合而为病的病机特点,疗效显著。 Objective: To observe the curative effect and mechanism of Zhengtian Pill combined with Chuanxiong Qingnao Granules in the treatment of children migraineso as to provide scientific basis for rehabilitation of children migraine.Methods: A total of 106 cases of children with migraine confirmed in the Neurology Department of our hospital between October 2013 and October 2015 were selected as the research object. These children were randomly divided into an experimental group and a control group,with 53 cases in each group. Patients in the control group were given Zhengtian Pill for treatmentwhereas those in the experimental group were treated with Zhengtian Pill combined with Chuanxiong Qingnao Granules. The clinical curative effect and changes of TCD after treatment in the two were observed. Results: The total effective rate in the experimental group was significantly higher than that in the control groupand the difference was statistically significant( P = 0. 026). Before treatment,no statistically significant difference was found in blood velocity of MCA,ACA,PCA,BA or VA between the two groups( P〉0. 05),After treatment,blood flow velocity of MCA,ACA,PCA,BA and VA was reduced in both groups( P〈0. 05) and all the indexes in the experimental group were registered to be lower than those in the control group and the difference was statistically significant( P〈0. 05). Before treatment,the degree of severity,duration and frequency of the headache were shown to be no statistically significant difference between the two groups( P〉0. 05),whereas after treatment,the degree of severity,duration and frequency of the headache in the two groups were all reduced( P〉0. 05). All the indexes in the experimental group were registered to be lower than those in the control group and the difference was statistically significant( P〈0. 05). Before treatment,there was no sta-tistically significant difference between the two groups in β-EP,ET,5-HT or NO( P〉0. 05). After treatment,signifi
出处 《中华中医药学刊》 CAS 北大核心 2017年第4期1017-1020,共4页 Chinese Archives of Traditional Chinese Medicine
基金 湖州市科技计划项目(2012YSB17)
关键词 正天丸 川芎清脑颗粒 儿童偏头痛 血管 神经 Zhengtian Pill Chuanxiong Qingnao Granules children migraine vessel nerve
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