摘要
目的:观察大剂量川芎联合西药治疗血管神经性头痛的临床疗效及对脑血流动力学的影响。方法:126例血管神经性头痛患者随机分为对照组(30例)、小剂量川芎组(31例)、中剂量川芎组(33例)、大剂量川芎组(32例)。对照组给予谷维素和氟桂利嗪治疗,其余3组分别给予小剂量、中剂量、大剂量川芎治疗。4组疗程均为8周。比较4组患者临床疗效,治疗前后头痛症状改善、脑血流动力学指标及组间不良反应。结果:4组患者临床疗效比较,差异有统计学意义(P<0.05),其中大剂量川芎组疗效最优,其次为中剂量川芎组,低剂量川芎组和对照组临床疗效比较,差异无统计学意义(P>0.05)。与治疗前比较,4组患者头痛视觉模拟评分(visual analogue scale,VAS)、头痛发作次数、头痛每次持续时间均明显降低,治疗后大剂量川芎组以上指标低于另外3组,中剂量川芎组低于小剂量川芎组和对照组,差异均有统计学意义(P<0.05);低剂量川芎组和对照组比较,差异无统计学意义(P>0.05)。与治疗前比较,4组患者基底动脉、大脑中动脉、大脑前动脉血管阻力指数(resistance index,RI)均明显降低,收缩期峰值血流速度(peak systolic velocity,PSV)明显增高,治疗后大剂量川芎组RI和PSV均优于其余3组,中剂量川芎组优于小剂量川芎组和对照组(P<0.05);低剂量川芎组和对照组比较,差异无统计学意义(P>0.05)。4组患者不良反应比较,差异无统计学意义(P>0.05)。结论:大剂量川芎联合西药治疗血管神经性头痛疗效显著,可最大限度改善患者疼痛症状,并调节脑血流动力学,且安全性好。
Objective:To observe the clinical effect of high-dose Chuanxiong(Sichuan lovage rhizome)combined with western medicine on angioneurotic headache and its influence on cerebral hemodynamics.Method:126 patients with angioneurotic headache were randomly divided into control group(30 cases),low-dose Chuanxiong group(31 cases),medium-dose Chuanxiong group(33 cases)and high-dose Chuanxiong group(32 cases).The control group was treated with oryzanol and flunarizine,while the other three groups were treated with low-dose,medium-dose and high-dose Chuanxiong respectively.The course of treatment in the four groups was 8 weeks.The clinical efficacy,headache symptoms,cerebral hemodynamic indexes and adverse reactions between the four groups were compared before and after treatment.Result:The clinical effects of the four groups were statistically significant(P<0.05),of which the high-dose Chuanxiong group had the highest effect,followed by the medium-dose Chuanxiong group,and the low-dose Chuanxiong group and the control group had no statistically significant difference(P>0.05).Compared with before treatment,the visual analogue scale(VAS),headache attack times and headache duration of the 4 groups of patients were significantly reduced.After treatment,the above indexes of high-dose Chuanxiong group were lower than those of the other 3 groups.The middle-dose Chuanxiong group was lower than the low-dose Chuanxiong group and the control group,the difference was statistically significant(P<0.05).There was no significant difference between the low dose group and the control group(P>0.05).Compared with before treatment,the resistance index(RI)of the basilar artery(BA),middle cerebral artery(MCA)and anterior cerebral artery(ACA)in the four groups were significantly reduced,and the peak systolic blood flow velocity(peak systolic)was significantly reduced After treatment,the RI and PSV of high-dose Chuanxiong group were better than the other three groups,the middle dose Chuanxiong group was better than the low-dose Chuanxiong group and
作者
尹毅
白永利
YIN Yi;BAI Yongli(Fifth Outpatient Department of Air Force No.986 Hospital,Xi'an Shannxi China 710061;Shannxi Province Academy of Chinese Medicine,Xi'an Shannxi China 710003)
出处
《中医学报》
CAS
2020年第7期1547-1550,共4页
Acta Chinese Medicine
基金
陕西省重点研发计划项目(2018SF-129)。
关键词
川芎
血管神经性头痛
脑血流动力学
阻力指数
峰值血流速度
视觉模拟评分
药物剂量
中西医结合
Chuanxiong(Sichuan lovage rhizome)
angioneurotic headache
cerebral hemodynamics
RI
PSV
VAS
drug dosage
integration of traditional and western medicine
