摘要
急性肺损伤(acute lung injury,ALI)为临床常见的急危重症,发病机制复杂,病死率较高。Toll受体4(Toll-like receptor 4,TLR-4)信号通路与炎症反应密切相关,在ALI的发病机制中起着重要的作用。近年来,研究发现一些中药复方及活性成分通过调节TLR-4信号通路达到防治ALI的作用。就TLR-4信号通路及其在ALI中的作用,以及以该通路相关分子为靶点防治ALI中药的研究进展做一综述。
Acute lung injury is clinical common critical disease and its pathogenesis is complicated and the mortality is high. Toll -like receptor 4 （TLR -4） signaling pathway is closely related to the inflammatory reaction and plays an important role in the pathogenesis of ALI. In recent years, studies have found that some traditional Chinese medicine compound and active ingredients could protect and treat ALl through regulating the TLR -4 signaling pathway. In this pa- per, we reviewed TLR- 4 signaling pathway, the role of TLR- 4 in ALl and the research progress of traditional Chinese medicine in the prevention and treatment of ALI via TLR -4 signaling pathway.
出处
《中华中医药学刊》
CAS
北大核心
2017年第4期802-805,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81303131)
关键词
急性肺损伤
TLR-4信号通路
活性成分
单味中药
中药复方
acute lung injury
TLR - 4 signaling pathway
active ingredient
single herb
Chinese herbal compound
