摘要
目的研究尼可地尔在治疗变异性心绞痛中的作用。方法收集某医院心内科2013年3月—2016年7月收治的变异性心绞痛患者92例随机分为试验组(46例)和对照组(46例)。在给予常规治疗基础上,试验组口服尼可地尔,对照组口服地尔硫卓,两组患者均治疗4周。观察两组治疗后的疗效及不良反应。结果试验组变异性心绞痛发作次数较治疗前减少80%以上的患者例数(显效)显著多于对照组(P<0.05);治疗4周后试验组总有效率显著高于对照组(P<0.05)。对照组治疗后心率显著低于试验组(P<0.05)。结论尼可地尔治疗变异性心绞痛的疗效和安全性更高。
Objective The purpose of the present study was to Evaluate curative effect and safety of nicorandil in treatment of variant angina. Methods Ninety-two patients with variant angina treated in the department of cardiology of our hospital from March 2013 to July 2016 were randomized and divided into trial group （n=46） and control group （n=46）. In addition of the conventional drug treatment,the control group was treated with oral diltiazem while the Trial group with nicorandil. Therapeutic effects and adverse reaction were compared between the two groups after four weeks of the Treatment. Reslllt The total effective rate in the trial group was significantly higher than that in the control group after four weeks of the Treatment （95.7% versus 73.9%,P〈0.05）. The number of cases that the Variant angina attack frequency decreased to over 80 per cent in the trialgroup were significantly greater than that in the control group after four weeks of The Treatment（P〈0.05）. The heart rate was significantly lower in control group than in trial group after four weeks of thetreatment （P〈 0.05）. Correlation Nicorandil is more higher curative effect and safety to control angina attack of patients with variant angina.
作者
丁平
陈红
张浩
DING Ping CHEN Hong ZHANG Hao(Department of Cardiology,No. 153 Hospital of Chinese PLA,Zhengzhou,Henan 450000,China)
出处
《实用医药杂志》
2017年第3期203-204,209,共3页
Practical Journal of Medicine & Pharmacy
