摘要
目的观察激光联合氨甲环酸、谷胱甘肽及维生素C治疗黄褐斑的临床效果。方法选取2014年1月~2016年1月期间在我院接受诊治的黄褐斑患者135例,将其随机分为A、B、C三组,每组各45例,A组给予激光治疗,B组给予氨甲环酸、谷胱甘肽及维生素C治疗,C组给予激光、氨甲环酸、谷胱甘肽及维生素C联合治疗,观察比较三组患者治疗前后黄褐斑面积及颜色评分,比较三组的临床疗效及不良反应发生情况。结果三组患者治疗后黄褐斑面积及颜色评分较治疗前均明显减小,且治疗后C组患者的黄褐斑面积及颜色评分明显小于A、B两组,P<0.05,差异具有统计学意义。C组治疗的总有效率明显高于A、B两组,P<0.05,差异具有统计学意义。A、B、C三组不良反应发生率分别为4.4%、6.7%、6.7%,组间差异不明显,P>0.05,差异无统计学意义。结论激光联合氨甲环酸、谷胱甘肽及维生素C治疗黄褐斑疗效确切,可有效改善黄褐斑面积及颜色,且不良反应少,值得推广应用。
Objective To observe the clinical effect of laser combined with tranexamic acid,glutathione and vitamin C in the treatment of chloasma.Methods 135 cases of chloasma patients who were treated in our hospital from January 2014 to January 2016 were randomly divided into three groups： group A,group B and group C,45 patients in each group,group A for laser treatment,B Group C was treated with tranexamic acid,glutathione and vitamin C. Group C was treated with laser,tranexamic acid,glutathione and vitamin C in combination. The chloasma area and color score were compared between the three groups before and after treatment,Compared the clinical efficacy of three groups and the occurrence of adverse reactions.Results The area and color score of chloasma in the three groups were significantly lower than those before treatment,and the chloasma area and color score of group C were significantly lower than those of group A and group B,P0.05,the difference was statistically significant significance. The total effective rate of group C was significantly higher than that of group A and B,P0.05,the difference was statistically significant. The incidence of adverse reactions in group A,B and C was 4.4%,6.7% and 6.7%,respectively. There was no significant difference between the two groups,P〈0.05,there was no significant difference between the two groups.Conclusion Laser combined with tranexamic acid,glutathione and vitamin C treatment of melasma effective,can effectively improve the area and color of chloasma,and less adverse reactions,it is worth promoting the application.
出处
《中国医疗美容》
2017年第3期46-48,共3页
China Medical Cosmetology
