摘要
目的探讨在青少年中进行维生素D(VD)补充和户外时间干预对25(OH)D水平的影响。方法 2015年4月,在阜阳某高职院校方便抽取3个班级,随机分配为VD补充组(n=55)、户外时间干预组(n=52)和对照组(n=63)。VD补充组被要求每日服用800 IU维生素D3,户外时间干预组被要求每日9点至15点户外时间至少半小时,干预时间为4周,对照组则不进行任何干预。在干预前后,对3组研究对象进行问卷调查(包括年龄、性别、居住地、VD相关健康行为、自评肤色、吸烟饮酒等),并采集指尖血以串联质谱法分析25(OH)D水平,比较干预前后3组25(OH)D间的差异。结果干预前,VD补充组、户外时间干预组和对照组的25(OH)D水平分别为15.5 nmol/L(95%CI 14.3~16.6 nmol/L)、16.5 nmol/L(95%CI 15.2~17.8 nmol/L)和16.0 nmol/L(95%CI 14.9~17.1 nmol/L),差异无统计学意义(F=0.77,P=0.464);干预后,VD补充组(56.8 nmol/L,95%CI 52.0~61.6 nmol/L)和户外时间干预组(54.3 nmol/L,95%CI 49.4~59.3 nmol/L)的25(OH)D水平均显著高于对照组(47.2 nmol/L,95%CI 42.7~51.7 nmol/L),差异有统计学意义(F=4.40,P=0.014)。干预前,3组研究对象VD缺乏率均为100%;干预后,VD补充组、户外时间干预组和对照组的3组VD缺乏率分别为40.0%(95%CI 27.7%~53.2%)、48.1%(95%CI 34.8%~61.5%)及65.1%(95%CI 52.9~76.1%)。以对照组作为参照,VD补充组在干预后VD缺乏风险显著下降(RR adj=0.33,95%CI0.15~0.72,P=0.005),户外时间干预组在干预后VD缺乏风险也有所降低,差异接近统计学意义(RR adj=0.48,95%CI 0.22~1.05,P=0.065)。结论青少年进行800 IU/d剂量的VD3补充或者每日有效户外时间不低于半小时,均可显著提高25(OH)D水平。
Objective To assess the effect of vitamin D（ VD） supplementation and outdoor time intervention on the 25（ OH） D level in adolescents. Methods In April2015,participants from three classes in a college of North Anhui were randomly assigned to VD supplementation group（ receive oral vitamin D3 of 800 IU/d for 4 weeks,n = 55）,outdoor time intervention group（ more than 30 min/d of outdoor between 9 am and 15 pm for 4 weeks,n = 52） and control group（ no any intervention,n = 63）. The data on demographic characteristics,behavior related to vitamin D and life style were evaluated by using questionnaire. 25（ OH） D level in finger-tip blood was measured by using LC-MS/MS. The differences of 25（ OH） D levels among 3 groups over 4 weeks were compared.Results On baseline,there was no significant difference（ F = 0. 77,P = 0. 464） on the25（ OH） D level among VD supplementation group（ 15. 5 nmol/L,95% CI 14. 3- 16. 6nmol/L）,outdoor time intervention group（ 16. 5nmol/L,95% CI 15. 2- 17. 8 nmol/L）and control group（ 16. 0 nmol/L,95% CI 14. 9- 17. 1 nmol/L）. However,the 25（ OH）D level of VD supplementation group（ 56. nmol/L,95% CI 52. 0- 61. 6 nmol/L） and outdoor time intervention group（ 54. 3 nmol/L,95% CI 49. 4- 59. 3 nmol/L） were significantly higher（ F = 4. 40,P = 0. 014） than that of the control group（ 47. 2 nmol/L,95% CI 42. 7- 51. 7 nmol/L） 4 weeks later. All participants among 3 group were all in VD deficiency（ 50 nmol/L） on baseline. After 4 weeks, the prevalence of VD deficiency among 3 group reduced to 40. 0%（ 95% CI 27. 7%- 53. 2%）,48. 1%（ 95%CI 34. 8%- 61. 5%） and 65. 1%（ 95% CI 52. 9%- 76. 1%）,respectively. Compared with the control,the risk of VD deficiency in VD supplementation group significantly decreased（ RRadj= 0. 33,95% CI 0. 15- 0. 72,P = 0. 005）,and the risk in the outdoor time intervention group also obviously decreased（ RRadj= 0. 48,95% CI 0. 22- 1. 05,P = 0. 065）,but did not reach statistical significance. Conclusion T
出处
《卫生研究》
CAS
CSCD
北大核心
2017年第2期207-212,共6页
Journal of Hygiene Research
基金
国家自然科学基金面上项目(No.81472991)
省级自然科学一般项目(No.KJ2015B006)
国家/省级大学生创新训练项目(No.201510366023/AH201410366100)
关键词
青少年
维生素D
户外时间
干预
adolescents
vitamin D
outdoor time
intervention
