摘要
目的评价兰州地区婴幼儿维生素D(VitD)营养状况,为合理补充VitD提供依据。方法以兰州地区住院婴幼儿为研究对象,液相色谱串联质谱法检测血清25-羟维生素D[25-(OH)D]水平。问卷调查VitD缺乏的相关因素,并行Logistic回归分析VitD缺乏的危险因素。结果 374名住院婴幼儿进入分析,其中男227名,女147名。①平均25-(OH)D水平为(30.40±14.88)ng·mL-1,73名(19.5%)25-(OH)D水平<20ng·mL-1(VitD缺乏),即使近3个月补充过VitD,仍有13名(10.2%)VitD缺乏。②VitD缺乏有明显季节差异(P=0.04),春季最高(29.2%,21/72名),秋季最低(13.1%,16/122名)。③Logistic回归分析显示,≤6月龄(OR=3.67,95%CI:1.25～10.76)、6月龄内纯母乳喂养儿(OR=40.94,95%CI:5.07～330.36)、部分母乳喂养儿(OR=12.21,95%CI:1.41～105.65)、未补充VitD(OR=5.21,95%CI:2.48～10.97)易出现VitD缺乏。结论兰州地区住院婴幼儿VitD营养状况有待改善,≤6月龄婴儿是VitD缺乏的高危人群。冬春季应加强婴幼儿VitD的补充,应鼓励婴幼儿坚持户外活动及补充VitD。
Objective To study vitamin D status of infants and toddlers hospitalized in Lanzhou and its relative factors in order to offer the evidence for supplying vitamin D reasonably. Methods The level of serum 25-（OH） D was determined as an indicator of the vitamin D status. Serum 25-（OH） D levels were measured by liquid chromatography-tandem mass spectrometry （LC-MS- MS）. Inpatient infants and toddlers aged 1 to 36 months were recruited in Lanzhou （36°03 N latitude）. Vitamin D External Quality Assessment Scheme（DEQAS） was used to detect the bias of 25-（OH） D test in our laboratory. The prevalence of vitamin D deficiency was based on the proposed definition of 〈 20 ng·mL^-1. Logistic regression was used to analyze potential relative factors of vitamin D deficiency surveyed by a questionnaire. Results Total of 374 inpatient infants were enrolled into the study, including 227 males and 147 females. ①The average levels of serum 25- （OH） D of subjects were （ 30.40± 14.88 ） ng·mL^-1 Serum 25- （OH）D deficiency was found in 19.5% infants and toddlers. There were still 10. 2% infants and toddlers with vitamin D deficiency even though they had taken vitamin D supplements recently. ②25-（ OH ）D levels varied with season （P = 0. 04 ）. Vitamin D levels were the lowest in spring, the deficiency was seen in 29% participants. The highest vitamin D level was presented in fall , but there were still 13% participants were Vitamin D deficiency.③Many infants under 6 months were lack of vitamin D seriously （OR =3.67,95% CI：1. 25 -10.76）. Compared with infants under 6 months fed with formula, those with pure breastfeeding and mixed feeding appeared to more likely to be vitamin D deficiency, OR was 40.941 （95% CI：5.07 -330.36） and 12.21 （95% CI： 1.41 - 105.65 ） , respectively. ④ Not taking vitamin D supplementation was significantly associated with an increased risk of deficiency （OR = 5.21,95% CI：2.48 - 10.97）. Conclusions Infants under 6 months were the high ri
出处
《中国循证儿科杂志》
CSCD
2013年第3期181-185,共5页
Chinese Journal of Evidence Based Pediatrics
关键词
维生素D
补充
婴幼儿
缺乏
营养
Vitamin D
Supplementation
Infants
Deficiency
Nutrition
