摘要
目的检测MMP-3、MMP-10和基质金属蛋白酶抑制剂2(TIMP-2)在结肠癌组织中的表达。方法采用免疫组织化学方法检测MMP-3、MMP-10及TIMP-2在60例结肠癌和26例癌旁正常组织中的表达。结果结肠癌组织中MMP-3、MMP-10和TIMP-2阳性表达率分别为76.7%、58.3%和66.7%,高于癌旁正常组织的15.4%、11.5%和3.84%(P<0.01)。MMP-3和MMP-10的表达均与肿瘤大小、浸润深度、淋巴结转移及TNM分期密切相关(P<0.05或P<0.01);TIMP-2表达与淋巴结转移密切相关(P<0.05)。MMP-3、MMP-10表达与TIMP-2表达有相关性(r=0.33、r=0.28,P<0.05)。结论 MMP-3、MMP-10和TIMP-2的高表达与结肠癌侵袭与转移密切相关,可以作为临床评估结肠癌进展及肿瘤预后的指标。
Objective To explore the expressions of MMP-3,MMP-10 and tissue inhibitor of metalloproteinase 2（TIMP-2）in colonic carcinoma tissues.Methods The expressions of MMP-3,MMP-10 and TIMP-2were detected by immunohistochemistry in colonic carcinoma tissues（group A,60cases）and tumor-adjacent normal tissues（group B,26cases）.Results The expressions of MMP-3,MMP-10 and TIMP-2in group A were 76.7%,58.3% and 66.7%,respectively,which were significantly higher than 15.4%,11.5% and 3.84%in group B（P〈0.01）.The expressions of MMP-3and MMP-10 were closely related to tumor size,depth of invasion,lymph node metastasis and TNM stage（P〈0.05 or P〈0.01）.TIMP-2 expression was closely related to lymph node metastasis（P〈0.05）.The expressions of MMP-3and MMP-10 were positively correlated to TIMP-2expression（r=0.33 and r=0.28,P〈0.05）.Conclusion Abnormally high expressions of MMP-3,MMP-10 and TIMP-2are closely related to the invasion and metastasis of colonic carcinoma and can be used as the important indicators for clinical evaluation of the progression and prognosis of colon cancer.
出处
《江苏医药》
CAS
2017年第5期349-351,F0003,共4页
Jiangsu Medical Journal
关键词
结肠癌
基质金属蛋白酶
基质金属蛋白酶抑制剂
Colonic carcinoma
Matrix metalloproteinase
Tissue inhibitor of metalloproteinase
