摘要
在心房颤动的治疗中,华法林发挥着抗凝作用,胺碘酮发挥着复律、维持窦性心律和减慢持续性房颤的心室率的作用,二者合用的可能性极大。然而,由于胺碘酮的使用,华法林相关的严重出血事件增加,给广大临床工作者带来极大的困惑与不便。解决好两药合用的难题,具有重要的实践价值。本文综述了华法林与胺碘酮合用的最新研究进展,提出了两药合用时应对策略,对于临床合理化应用华法林具有积极的指导意义。
Anti-coagulation and heart rate control are very important in the treatment of atrial fibrillation.It has been proved by a large number of clinical trials that warfarin is effective in preventing thrombo-embolism in non-valvular atrial fibrillation.Amiodarone is a commonly used oral anti-arrhythmic drug and plays an important role in restoration of sinus rhythm in patients with atrial fibrillation,which therefore demonstrates great possibilities of combining usage with amiodarone.However,warfarin-related severe bleeding events increase as used with amiodarone,which bring great confusion and inconvenience to clinicians.So,it is necessary to solve the problem of the combination of these two drugs.This article reviews the recent progress on the interaction between warfarin and amiodarone,and proposes strategies when use these two drugs together,which is of great significance for the rationalization of drugs treatment of atrial fibrillation.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2017年第2期215-221,共7页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
国家自然科学基金项目(81460570)
关键词
华法林
胺碘酮
药物相互作用
房颤
抗凝
warfarin
amiodarone
drug-drug interaction
atrial fibrillation
anticoagulation
