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不同剂量氯吡格雷对急性冠脉综合征患者抗血小板治疗的临床研究 被引量:1

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摘要 目的探讨不同负荷剂量氯吡咯雷对急性冠脉综合征(ACS)患者抗血小板治疗的临床疗效。方法入选96例2007-05~2008-12在我院诊断为ACS的患者。随机分别选入给予300mg、450mg和600mg负荷剂量氯吡格雷组,观察服药前及服药后2、4、24和48h血小板聚集率,并观察两组患者服药2周内出血、血栓性血小板减少性紫癜(TTP)以及白细胞减少等与氯吡格雷相关的不良反应。结果450mg与300mg氯吡格雷负荷剂量组血小板聚集率降低无差异。600mg组较300mg、450mg组在服药2、4h血小板聚集率降低更为显著(P<0.05),24h无差异。住院期间,两组严重出血事件发生情况差异无统计学意义(P>0.05)。结论服用600mg氯吡格雷能产生更强的血小板抑制作用。
机构地区 黑龙江省医院
出处 《黑龙江医学》 2009年第6期423-425,共3页 Heilongjiang Medical Journal
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