摘要
目的探讨动态监测ICU非甲状腺疾病危重症患者甲状腺激素水平与患者预后结局的关系。方法方便选取2015年1月—2016年1月该院ICU内收治的非甲状腺疾病重症患者93例作为研究对象。根据APACHE评分分为危重症组(35例)、严重危重症组(39例)、极危重症组(19例),另选取同期普通病房住院的非甲状腺疾病非危重症患者50例作为对照组,动态监测各组患者甲状腺激素水平及不同预后结局危重症患者甲状腺激素水平。结果入院24 h、3 d、7 d时4组患者TT3、TT4、TSH、FT3、FT4水平比较差异有统计学意义(P<0.05),并且极危重症组各项指标最低;存活的危重症患者与死亡患者TT3(0.81±0.24)nmol/L vs[(0.55±0.22)nmol/L],TT4[(90.39±20.14)nmol/L vs(63.24±16.71)nmol/L],TSH[(1.39±1.15)m U/L vs(1.13±1.72)m U/L],FT3[(2.34±0.74)pmol/L vs(1.47±0.52)pmol/L,FT4(15.39±5.44)pmol/L vs(12.19±3.85)pmol/L]水平比较差异有统计学意义(P<0.05)。结论非甲状腺疾病危重症患者甲状腺激素水平与患者临床预后结局密切相关,临床应重视ICU内危重症患者甲状腺激素水平的变化,有助于及时纠正与治疗,改善患者临床预后结局。
Objective To discuss the dynamic monitoring of level of thyroid hormone and prognosis of patients with nonthyroidal critical illness in ICU. Methods Convenient selection 93 cases of patients with nonthyroidal critical illness in ICU from January 2015 to January 2016 were selected as the research objects and divided into the critical ill group（ 35 cases）, severe critical ill group（30 cases） and extremely severe critical ill group（19 cases）, and 50 cases of patients with nonthyroidal critical illness in the common ward at the same period were selected as the control group, and the level of thyroid hormone and prognosis in each group were dynamically monitored. Results There were obvious differences in the TT3,TT4,TSHF,T3,FT4 levels at 24 h,3 d,7 d after admission between the four groups（P〈0.05）, and various indexes in the extremely severe critical ill group were lowest, and the differences in the TT3,TT4,FSH,FT3,FT4 levels between the critical illness patients and death patients had statistical significance [（0.81 ±0.24）nmol/L vs（0.55 ±0.22）nmol/L,（90.39 ±20.14）nmol/L vs 63.24 ±16.71）nmol/L,（1.39 ±1.15）m U/L vs（1.13 ±1.72）m U/L,（2.34±0.74）pmol/L vs（1.47±0.52）pmol/L,（15.39±5.44）pmol/L vs（12.19±3.850）pmol/L]（P〈0.05）. Conclusion The correlation between the level of thyroid hormone of patients with nonthyroidal critical illness in ICU and clinical prognosis of patients,and we should pay attention to the changes of level of thyroid hormone of patients with nonthyroidal critical illness in ICU, which contributes to timely correction and treatment and improve the clinical prognosis outcome.
出处
《中外医疗》
2017年第4期9-11,共3页
China & Foreign Medical Treatment
基金
东莞市医疗卫生科技计划一般项目(2016105101150)
