摘要
目的探讨阿司匹林和氯吡格雷联合应用于进展性脑卒中的治疗效果。方法将108例进展性脑卒中患者分成两组,对照组行阿司匹林治疗,观察组在此基础上加用氯吡格雷,对比两组临床疗效。结果观察组治疗总有效率为96.3%,高于对照组的74.07%;其治疗30天的血清hs-CRP含量和NIHSS评分为(3.14±1.18)mg/L、(4.09±1.02)分,低于对照组的(5.89±2.10)mg/L、(6.49±1.00)分;其ADL评分为(65.10±5.06)分,高于对照组的(50.11±7.03)分,差异有统计学意义(P<0.05)。两组不良反应均为1.85%,差异无统计学意义(P>0.05)。结论对进展性脑卒中患者联合应用阿司匹林和氯吡格雷治疗疗效较好,不良反应较少。
Objective To investigate the therapeutic effect of aspirin and clopidogrel in patients with progressive stroke. Methods 108 patients with progressive stroke were divided into two groups, the control group treated with aspirin, the observation group added clopidogrel on the basis of the two groups of clinical efficacy. Results The total effective rate was 96.3% in the observation group and 74.07% in the control group. The levels of hs-CRP and NIHSS in the treatment group were （3.14± 1.18）mg/L, （4.09± 1.02）, was lower than the control group （5.89±2.10）mg/L and （6.49±1.00） respectively. The ADL score of the control group was （65.10±5.06） higher than that of the control group（50.11±7.03）, P〈0.05. Adverse reactions were 1.85%, there was no difference statistically signifcance （P〉0.05）. Conclusion The combination of aspirin and clopidogrel in patients with progressive stroke has better efficacy and less side effects.
作者
贺大伟
李臻
HE Dawei LI Zhen(Department of Pharmacy, Central Hospital of Zaozhuang Mining Group, Zaozhuang Shandong 277800, Chin)
出处
《中国继续医学教育》
2017年第4期165-166,共2页
China Continuing Medical Education
