摘要
目的探讨血清分泌型卷曲相关蛋白5(SFRP5)与T2DM及颈动脉粥样硬化(CAS)的相关性。方法根据颈动脉彩色多普勒超声结果,将56例T2DM患者分成T2DM合并CAS组(CAS组)28例和单纯CAS组(NAS组)28例,同时选取同期正常对照组(NGT组)28名。ELISA测定血清SFRP5浓度。结果 CAS组和NAS组血清SFRP5浓度较NGT组低[(114.36±25.48)vs(48.19±11.82),(43.88±8.19)pg/ml,P<0.01];CAS组与NAS组血清SFRP5比较,差异无统计学意义。Pearson相关分析表明,血清SFRP5与年龄、TG、高敏C反应蛋白(hsC-RP)、FPG、FIns、HOMA-IR、HbA_1c、LDL-C、BMI呈负相关(r=-0.614,-0.160,-0.331,-0.682,-0.467,-0.580,-0.706,-0.339,-0.322,P<0.01),与HDL-C呈正相关(r=0.386,P<0.01),与性别、TC、SBP、DBP无相关性(P>0.05)。多元线性逐步回归结果示,在排除混素因素后,年龄、FIns、HbA_1c是血清SFRP5的影响因素。结论 T2DM患者血清SFRP5浓度较正常人低,SFRP5可能是T2DM的保护因素,或可改善IR,该蛋白的合成可能有助于延缓或逆转T2DM的发生与进展,为T2DM患者的防治提供了新思路。
Objective To investigate the relationships between plasma secreted frizzled-related protein（SFRP）5level with type 2diabetes（T2DM）and carotid atherosclerosis（CAS）. MethodsAccording to the results of carotid color Doppler ultrasound,56T2 DM patients were divided into 28 with carotid atherosclerosis（CAS group）and 28 without carotid atherosclerosis（NAS group）.28 healthy volunteers served as normal control（NC group）.Serum SFRP5 was measured by ELISA. Results The level of serum SFRP5 in T2DM patients was lower than NC group（114.36±25.48）vs（48.19±11.82）,（43.88±8.19）pg/ml,（P〈0.01）.The difference of serum SFRP5 between CAS and NAS group shared no statistical significance [CAS（43.88±8.19）vs NAS（48.19±11.82）pg/ml,P 〉0.05].Pearson correlation analysis showed that serum SFRP5 was negatively correlated with age,TG,hsC-RP,FPG,FIns,HOMA-IR,HbA1 c,TC,LDL-C and BMI（P〈0.01）,and positively correlated with HDL-C（P〈0.01）.There were no significant correlations between SFRP5 and gender,TC,systolic blood pressure（SBP）and diastolic blood pressure（DBP）（P〉0.05）.Multiple linear regression results showed that age,FIns and HbA1 c were independent influencing factors of serum SFRP5. Conclusion SFRP5 may be a protective factor for T2 DM by ameliorating insulin resistance which may provide a new clue for the prevention and treatment of T2 DM.
作者
胡兴娜
成兴波
闵幸丽
HU Xing-na CHENG Xing-bo MIN Xing-li(Department of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2017年第3期208-212,共5页
Chinese Journal of Diabetes
基金
上海市糖尿病重点实验室开放课题资助(SHKLD-KF-1403)
关键词
糖尿病
2型
血清分泌型卷曲相关蛋白5
颈动脉粥样硬化
胰岛素抵抗
Diabetes mellitus,type 2
Plasma secreted frizzled-related protein 5（SFRP5）
Carotid atherosclerosis（CAS）
Insulin resistance（IR）
