摘要
目的探讨T2DM患者大血管病变与踝臂脉搏波传导速度(baPWV)的相关性。方法选取T2DM患者284例,根据是否患有T2DM合并大血管病变分为T2DM合并大血管病变组139例和单纯T2DM组145例。检测两组baPWV和其他生化指标。结果两组baPWV、高敏C反应蛋白(hsC-RP)和年龄比较,差异有统计学意义(P<0.05)。相关性分析显示,baPWV异常与DBP、hsC-RP和年龄呈正相关。二元Logistic回归分析显示,DBP、FPG、HbA_1c、hsC-RP和年龄是T2DM合并大血管病变的影响因素,FPG和TC是危险因素。受试者工作特征(ROC)曲线下面积为0.641,当baPWV切点为18.23m/s时,其敏感性与特异性分别为83.5%和43.4%,具有一定的诊断价值。结论 T2DM大血管病变与baPWV呈一定的相关性,可能与hsC-RP的升高对baPWV的影响有关,对T2DM大血管病变具有一定的诊断价值。
Objective To investigate the correlation between macrovascular disease and ankle brachial pulse wave velocity（baPWV）in patients with type 2diabetes（T2DM）. Methods 284T2 DM were selected and divided into group with macrovascular disease（n=139）and group without macrovascular disease（n=145）.BaPWV and other biochemical parameters were measured and compared between two groups. Results There were significant differences of baPWV,high sensitive C reactive protein（hsC-RP）and age between two group（P〈0.05）.Correlation analysis showed that abnormal baPWV was positively correlated with DBP,hsC-RP and age.Logistic regression analysis showed that DBP,FPG,HbA1 c,hsC-RP and age were influence factors of T2 DM complicated with macrovascular disease,FPG and TC were the risk factor.The area under ROC curve was 0.641.When baPWV 18.23m/s was taken as cut off point,the sensitivity and specificity were 83.5% and 43.4%,respectively. Conclusion There is a certain correlation between T2 DM macrovascular disease and baPWV,which may be related to the increase of hsC-RP.
作者
唐世凡
王朝晖
程锡华
李婷
董晓雁
TANG Shi-fan WANG Zhao-hui CHENG Xi-hua et al(Department of Cardiovascular Medicine , Wuhan No. 3 Hospital , Wuhan 430074 ,Chin)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2017年第3期204-207,共4页
Chinese Journal of Diabetes
基金
湖北省武汉市自然科学基金(WX10B04)
关键词
糖尿病
2型
踝臂脉搏波传导速度
大血管病变
高敏C反应蛋白
Diabetes mellitus,type 2
Brachial-ankle pulse wave velocity（baPWV）
Vascular lesions
Hypersensitive C-reactive protein（hsC-RP）
