摘要
目的:探讨S100β与非急性期脑梗死的关系及辛伐他汀治疗后的变化。方法:选取我院收治的60例非急性期脑梗死患者为观察组,60例健康体检者为对照组。观察组患者口服辛伐他汀,40mg,每晚1次。分别于用药前、用药6个月、用药1年时采血,采用酶联免疫吸附双抗体夹心法(ELISA)测定血清S100β的含量。结果:观察组患者用药前S100β水平高于对照组,但无统计学意义(P>0.05);服用辛伐他汀后S100β水平与治疗前及对照组比较差异无统计学意义(P>0.05)。结论:S100β与非急性期脑梗死无相关性,辛伐他汀对血清S100β亦无作用。
Objective：To study the relationship between S100β and non - acute cerebral infarction and changes after the treatment with simvastatin. Methods ：60 cases of non - acute cerebral infarction admitted were in the observation group, 40 cases checked up as healthy objects were in the control group. The observation group took simvastatin orally 40rag QN. Blood sampling was collected before administering medicine, after 6 months＇and 12 monthsJadministration, respectively. And then serum S100 was detected by using double -antibody sandwich enzyme -linked immune sorbent assay method （ELISA）. Results： Before administration of simvastatin, serum S100β content in the observation group was higher than that of the control group, but there was no significant difference （ P 〉 0.05 ）. There was no significant difference in S100β content in the observation group before and after the treatment of simvastatin, and there was no significant change between the two groups （ P 〉 0.05 ）. Conclusion ： S100β and non - acute cerebral infarction are unrelated, and there is no effect of simvastatin on serum S100β.
出处
《包头医学院学报》
CAS
2017年第3期80-81,共2页
Journal of Baotou Medical College
