摘要
目的研究再程放疗在头颈部复发癌及第二原发恶性肿瘤治疗中的临床效果。方法选取头颈部复发癌及第二原发恶性肿瘤患者60例,根据治疗方法不同将患者分为对照组30例和观察组30例。对照组采用化疗方法治疗,观察组在对照组基础上联合再程放疗,比较2组治疗效果及不良反应发生率。结果观察组治疗有效率为60.0%、临床获益率为70.0%,显著高于对照组的有效率33.3%、获益率43.3%(P<0.05);观察组治疗后并发症发生率为43.3%,显著低于对照组的73.3%(P<0.05)。观察组SF-36量表中躯体健康、心理健康、社会得分以及疾病症状评分,显著高于对照组(P<0.05)。结论头颈部复发癌及第二原发恶性肿瘤患者在化疗治疗基础上联合再程放疗治疗效果理想,不良反应发生率较低,值得推广应用。
Objective To study the re-irradiation of recurrent head and neck cancer and second primary cancer treat -ment in the clinical effect .Methods 60 cases of second primary malignancies and recurrent head and neck cancer ,according to the different methods of treatment ,were divided into the control group and the observation group ,each with 30 cases,chemotherapy treatment ,re-irradiation combined with the observation group in the control group ,based on the 2 groups were compared treatment and incidence of adverse reactions .Results The response rate was 60.0%,clinical benefit rate was 50.0%,which were signifi-cantly higher than the effective rate of 50.0%benefit rate was 43.3%（P〈0.05）;complications of the observation group after treatment was 43.3%,which was significantly lower than 73.3%in the control group（P〈0.05）.SF-36 in physical health,men-tal health,social disease symptom score and score of the observation group were significantly higher （P〈0.05）.Conclusion Head and neck cancer recurrence and second primary malignancies in patients with joint re -irradiation treatment over chemothera-py treatment based on the low incidence of adverse reactions ,should be widely applied .
出处
《实用癌症杂志》
2017年第3期508-510,共3页
The Practical Journal of Cancer
关键词
再程放疗
头颈部复发癌
第二原发恶性肿瘤
治疗效果
Re-irradiation
Recurrent head and neck cancer
Second primary malignancies
Treatment effect
