摘要
目的:观察独活寄生汤对风寒湿痹型关节炎患者的疗效,并探讨其对关节液中炎症因子、氧化应激及脂肪细胞因子的影响。方法:选取东莞市中医院诊断及治疗的风寒湿痹型关节炎患者124例,按随机数字表法分组,对照组(62例)予以常规治疗,观察组(62例)在对照组基础上予以独活寄生汤治疗,观察并记录两组患者临床症状评分、关节液指标及脂肪细胞因子水平,同时比较两组患者临床疗效及并发症状况。结果:对照组治疗有效率低于观察组(P<0.05);与治疗前比较,两组患者治疗后视觉模拟评分法(visual analogue scale,VAS),西安大略和麦克马斯特骨关节炎调查量表(Western Ontario and Mc Master Universities Osteoarthritis,WOMAC)评分均降低,Lyshom评分升高,关节液中肿瘤坏死因子-α(tumor necrosis factoralpha,TNF-α),白细胞介素-6(interleukin-6,IL-6)及白细胞介素-1β(interleukine-1 beta,IL-1β)表达水平降低,关节液一氧化氮(nitric oxide,NO),丙二醛(malondialdehyde,MDA)水平降低,超氧化物歧化酶(superoxide dismutase,SOD)水平升高,脂联素(adiponectin,APN)水平升高,瘦素(leptin)及内脂素(visfatin)水平降低(P<0.05);与对照组比较,观察组治疗后VAS,WOMAC量表评分较低,Lyshom评分较高,关节液TNF-α,IL-6及IL-1β水平较低,关节液NO,MDA水平较低,SOD水平较高,APN水平较高,leptin及visfatin水平较低(P<0.05)。结论:独活寄生汤能够使关节炎患者受益,可能与其减少关节液中炎症因子表达及抑制氧化应激有关。
Objective： To observe the clinical efficacy of Duhuo Jisheng Tang for wind-cold-damp retention type arthritis,and investigate its effects onsynovial fluid inflammatory factors, oxidative stress and adipokines. Method： The 124 patients diagnosed of wind-cold-damp retention type arthritis in Dongguan Hospital of Traditional Chinese Medicine were selected and randomly divided into control group（ 62 cases） and observation group（ 62 cases）. Patients in control group received conventional therapy,and patients in observation group also received Duhuo Jisheng Tang based on treatment in control group. Clinical symptom scores,synovial fluid indexes,and adipokines in both groups were observed and recorded; the clinical efficacy and complications were compared between two groups after treatment. Result： The effective rate in control group was lower than that in observation group（ P〈0. 05）. As compared with the levels before treatment,Visual analogue scale（ VAS） and Western Ontario and Mc Master Universities Osteoarthritis（ WOMAC） scores were decreased. Lyshom scores were increased; tumor necrosis factor-α（ TNF-α）,interleukin-6（ IL-6） and interleukine-1β（ IL-1β） in synovial fluid were decreased; nitric oxide（ NO）,malondialdehyde（ MDA） levels in synovial fluid were decreased; superoxide dismutase（ SOD） and adiponectin（ APN） levels were increased. Leptin and visfatin levels were decreased after treatment in both groups,all with significant difference（ P〈0. 05）. As compared with the control group,VAS and WOMAC scale scores were lower in observation group after treatment,Lyshom score was higher; synovial fluid TNF-α,IL-6 and IL-1β levels were lower; NO and MDA levels were lower. SOD level was higher. APN level was higher,and the levels of leptin and visfatin were lower,all with significant difference（ P〈0. 05）. Conclusion：Duhuo Jisheng Tang is very effective for wind-cold-dampretention type arthritis,and its mechanism may be associated with reducing the l
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2017年第6期186-191,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
广东省中医药管理局科研基金项目(20111079)
关键词
独活寄生汤
风寒湿痹型关节炎
炎症因子
氧化应激
脂肪细胞因子
Duhuo Jisheng Tang
wind-cold-dampretention type arthritis
inflammatory factors
oxidative stress
adipokines
