摘要
胆汁酸作为一种生理洗涤剂,不仅能够促进脂类物质的消化吸收,而且可能是潜在的致癌因素。体内胆汁酸蓄积时,会导致胆汁淤积性肝硬化甚至肝癌。细胞核受体FXR及细胞膜受体TGR5对胆汁酸的亲和力较高,这些受体相互协调以保持胆汁酸水平相对稳定。调节胆汁酸介导的信号转导通路,形成一个有效的防御机制,可抑制胆汁酸的致癌性。FXR-/-小鼠血清及肝脏胆汁酸水平明显升高,可以观察到肝脏炎症及纤维化的发生,并自发形成肝癌;小鼠缺乏TGR5也可造成严重的肝脏损伤。本文就胆汁酸及其受体与肝癌发生发展的关系做一综述。
Bile acids are physiological detergent molecules which can not only facilitate the absorption of lipophilic nutrients,but may be a potential carcinogenic factor. When bile acids accumulate,it will lead to cholestatic cirrhosis and hepatocellular carcinoma. Both receptors which possess particular binding affinities for certain bile acids coordinate with each other tightly to maintain a relatively stable level of bile acids,regulating signal transduction pathways which bile acids mediated,and forming an effective defense mechanism to inhibit the carcinogenic effect of bile acids. Fxr-null mice accumulate high hepatic levels of BAs resulting in inflammation and fibrosis of liver,which were found to spontaneously develop hepatocellular carcinomas,and lacking TGR5 can also cause severe liver damage to the mice. This article reviewed the connections between bile acids with their receptors and hepatocellular carcinoma.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2017年第5期525-529,共5页
Chinese Journal of New Drugs
基金
国家自然科学基金资助项目(81503130)
天津市应用基础与前沿技术研究计划(14JCQJC13000)
关键词
胆汁酸
肝癌
FXR
TGR5
bile acids
hepatocellular carcinoma
FXR
TGR5
