摘要
目的观察虎藤组方煎剂治疗急性痛风性关节炎的临床疗效及分子机制。方法急性痛风性关节炎患者96例,随机数字表法等分为治疗组与对照组,治疗组采用中药虎藤组方煎剂治疗,对照组使用秋水仙碱治疗,疗程1周。ELISA法测定血清白细胞介素-1β(Interleukin-1β,IL-1β)。结果临床总疗效、血沉及血清IL-1β的水平,两组没有统计学差异(P>0.05);治疗组显效率高于对照组(P<0.05),治疗组血尿酸低于对照组(P<0.05),治疗组胃肠道不良反应低于对照组(P<0.05)。结论虎藤组方可能通过降低血尿酸及血清IL-1β的水平,改善急性痛风性关节炎的症状,且胃肠道不良反应少。
Obiective To observe the clinical efficacy of Huteng Zufang on acute gouty arthritis and explore its mechanism and adverse effects.Methods Serum samples were collected from 96 acute gouty arthritis patients who took Huteng Zufang decoction as treatment group and took colchicine tablets as control group,48 cases in each group for 1 week.ELISA was used to detect the levels of serum interleukin-1β（IL-1β）.Results The total effective rate and the levels of serum IL-1β in the two groups were not statistically significant（P〈0.05）.There was more markedly effective rate in treatment group than that in control group.The levels of serum uric acid in treatment group were lower than those of the control group（P〈0.05）.Gastrointestinal adverse effects in treatment group were fewer than those of the control group（P〈0.05）.Conclusion Huteng Zufang can improve the clinical symptoms of acute gouty arthritis by lowering the levels of serum uric acid and IL-1β and have fewer gastrointestinal adverse effects.
作者
徐倩
李盈
郝秀仙
姚民秀
XU Qian LI Ying HAO Xiu-xian YAO Min-xiu(The Central Hospital of Qingdao, Qingdao 266042, Chin)
出处
《现代中药研究与实践》
CAS
2017年第1期71-73,共3页
Research and Practice on Chinese Medicines
基金
青岛市中医科技项目(2014-zyy023)
