摘要
目的:观察活血通络汤内服联合活络术治疗神经根型颈椎病(气虚血瘀证)的临床疗效及对血清白细胞介素-1β(IL-1β),肿瘤坏死因子-α(TNF-α),白细胞介素-6(TIL-6)水平的影响。方法:采用随机按数字表法将200例神经根型颈椎病患者分为对照组101和观察组99例。对照组口服用根痛平颗粒,2袋/次,2次/d;观察组采用活络术注射穴位,1次/d,7次为1个疗程,休息1周后进行下1个疗程,同时采用活血通络汤内服,1剂/d,两组疗程均为4周。记录两组疼痛视觉模拟评分(VAS)和颈椎病评价量表评分(CASCS),检测治疗前后血液流变学,检测治疗前后患者血清白细胞介素-1β(IL-1β),肿瘤坏死因子-α(TNF-α),白细胞介素-6(IL-6)水平。结果:观察组和对照组临床总有效率分别为90.1%和73.27%,观察组优于对照组(P<0.05);治疗后观察组VAS评分低于对照组(P<0.01),CASCS评分高于对照组(P<0.01);观察组全血黏度高切、中切、低切和血浆黏度均比治疗前下降(P<0.01),观察组全血黏度高切和血浆黏度明显低于对照组(P<0.01);治疗后观察组治疗后体内TNF-α和IL-1β,IL-6水平明显低于对照组(P<0.01)。结论:活血通络汤内服联合活络术治疗神经根型颈椎病(气虚血瘀证)临床疗效显著,其作用机制可能与其改善血液流变学和降低血清IL-1β,TNF-α,IL-6水平相关。
Objective： To observe the therapeutic efficacy of Huoxue Tongluo decoction combined with Huoluo theray in the treatment of nerve-root type cervical spondylosis（ Qi stagnation and blood stasis syndrome）and its effect on serum interleukin-1β（ IL-1β）, tumor necrosis factor-α（ TNF-α）, interleukin-6（ IL-6）. Method： Totally 200 patients with nerve-root type cervical spondylosis were divided into the control group（ 101cases） and the observation group（ 99 cases）,respectively by random number table. The control group orally took Gentongping pellet,2 bags / time,2 times / d. The observation group was treated by Huoluo therapy,1 time / d,7times / course,with an interval of one week between two courses; Meanwhile,it also orally took Huoxue Tongluo decoction,1 dose / d. The course of treatment were 4 weeks for both groups. visual analogue scale（ VAS） score and visual analogue scale（ CASCS） score were recorded for both groups. Serum IL-1β,TNF-α and IL-6 were detected before and after the treatment. Result： The total effective rate of treatment and control groups was respectively 90. 1% and 73. 27%,with a significant difference between them（ P〈0. 05）. After the treatment,VAS score of the observation group was lower than that of the control group（ P〈0. 01）,while CASCS score in the observation group was obviously higher than that of the control group（ P〈0. 01）. After the treatment,high shear,median shear,low shear and plasma viscosity in the observation group was obviously lower than that of the control group（ P〈0. 01）,with significant differences in high shear viscosity of blood and plasma viscosity（ P〈0. 01）.Serum IL-1β,TNF-α,IL-6 in the observation group were lower than that of the control group（ P〈0. 01）.Conclusion： Huoxue Tongluo decoction combined with Huoluo therapy in the treatment of nerve-root type cervical spondylosis（ Qi stagnation and blood stasis syndrome） shows a significant clinical efficacy. Its mechanism may be correlated wit
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2015年第17期181-185,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
河北科技厅科研项目(132777216)
