摘要
目的探讨双歧杆菌四联活菌联合谷维素作用于肠易激综合征的临床效果。方法 52例肠易激综合征患者,采用电脑随机分组的方式分为观察组(28例)和对照组(24例)。两组患者在门诊收治后均接受匹维溴铵口服治疗,在此基础上观察组采用双歧杆菌四联活菌联合谷维素治疗,对照组采用谷维素治疗。比较两组患者的治疗效果、精神状态及不良反应发生情况。结果观察组治疗总有效率高于对照组,差异具有统计学意义(χ~2=4.3797,P<0.05)。治疗后,观察组汉密尔顿抑郁量表(HAMD)评分为(10.1±2.3)分,低于对照组的(12.7±3.4)分,差异具有统计学意义(t=3.2691,P<0.05);观察组汉密尔顿焦虑量表(HAMA)评分为(9.9±2.6)分,低于对照组的(12.1±2.9)分,差异具有统计学意义(t=2.8842,P<0.05)。两组不良反应发生率比较差异无统计学为意义(P>0.05)。结论在肠易激综合征的临床治疗中加入双歧杆菌四联活菌联合谷维素治疗具有较好的临场效果,方法值得借鉴。
Objective To investigate clinical effect by viable bifidobacterium tetravaccine combined with oryzanol in the treatment of irritable bowel syndrome. Methods A total of 52 patients with irritable bowel syndrome were divided by computer random allocation method into observation group（28 cases） and control group（24 cases）. Both groups received pinaverium bromide by oral administration for treatment after outpatient admission. The observation group received additional viable bifidobacterium tetravaccine combined with oryzanol for treatment, and the control group received oryzanol instead for treatment. Curative effects, mental state and adverse reactions were compared between the two groups. Results The observation group had higher total effective rate in treatment than the control group, and their difference had statistical significance（χ^2=4.3797, P〈0.05）. After treatment, the observation group had Hamilton depression scale（HAMD） score as（10.1±2.3） points, which was lower than（12.7±3.4） points in the control group, and their difference had statistical significance（t=3.2691, P〈0.05）. The observation group had lower Hamilton anxiety scale（HAMA） score as（9.9±2.6） points than（12.1±2.9） points in the control group, and the difference had statistical significance（t=2.8842, P〈0.05）. There was no statistically significant difference of incidence of adverse reactions between the two groups（P〉0.05）. Conclusion Implement of viable bifidobacterium tetravaccine combined with oryzanol shows excellent clinical effect in the treatment of irritable bowel syndrome, and this method is worth referring.
作者
胡凤艳
HU Feng-yan(Department of Internal Medicine, Liaoning Beizhen City Second People＇s Hospital, Beizhen 121308, China)
出处
《中国实用医药》
2017年第3期110-112,共3页
China Practical Medicine
关键词
肠易激综合征
双歧杆菌四联活菌
谷维素
Irritable bowel syndrome
Viable bifidobacterium tetravaccine
Oryzanol
