摘要
目的探讨匹维溴胺联合米氮平治疗肠易激综合征的临床疗效及其对神经肽Y水平的影响。方法选取60例肠易激综合征患者作为研究对象,将其随机均分为观察组和对照组各30例,对照组采用匹维溴胺治疗,观察组采用匹维溴胺联合米氮平治疗,比较两组患者单项症状疗效、临床疗效及治疗前后的神经肽Y水平。结果两组患者在腹痛及大便性状改变方面比较差异均具有统计学意义(P<0.05),在腹胀及排便异常方面比较差异均无统计学意义(P>0.05);观察组治疗有效率为86.7%,高于对照组的56.7%,差异具有统计学意义(P<0.05);观察组治疗前及治疗后神经肽Y水平分别为(39.8±10.1)ng/L及(52.3±12.4)ng/L,对照组为(39.9±9.8)ng/L及(46.2±11.8)ng/L,两组治疗后神经肽Y水平较治疗前显著升高(P<0.05),观察组治疗后神经肽Y水平明显高于对照组治疗后,差异具有统计学意义(P<0.05)。结论匹维溴胺联合米氮平治疗肠易激综合征能明显提高患者神经肽Y水平,临床疗效显著,可在临床上推广应用。
Objective To investigate the clinical effect of pinaverium bromide combined with mirtazapine in the treatment of irritable bowel syndrome and the influence on the level of neuropeptide Y. Methods Sixty patients of irritable bowel syndrome were selected as research objects, which were randomly divided into the observation group and the control group, each with 30 cases. The control group applied pinaverium bromide for treatment, while the observation group was treated with pinaverium bromide combined with mirtazapine. Neuropeptide Y levels before and after treatment, as well as the symptom curative effect were compared between the two groups. Results There were statistically significant differences in abdominal pain and change of character of stool effect between the two groups（P〈0.05）, but there was no significance difference in terms of abdominal distension and abnormal defecation effect（P〉0.05）. The effective rate of the observation group was 86.7%, which was significantly higher than 56.7% in the control group, with statistically significant difference（P〈0.05）. Before and after therapy, neuropeptide Y level were（39.8±10.1） ng/L and（52.3±12.4） ng/L in the observation group,（39.9±9.8） ng/L and（46.2±11.8） ng/L in the control group. The neuropeptide Y level of the two groups after treatment were significantly higher than that before treatment（P〈0.05）, and the levels of the observation group after treatment were significantly higher than that of the control group（P〈0.05）. Conclusion Pinaverium bromide combined with mirtazapine in the treatment of irritable bowel syndrome can significantly improve the level of neuropeptide Y, which has good clinical curative effect and can be widely applied in clinical practice.
出处
《海南医学》
CAS
2014年第23期3458-3460,共3页
Hainan Medical Journal
关键词
匹维溴胺
米氮平
肠易激综合征
神经肽Y
Pinaverium bromide
Mirtazapine
Irritable bowel syndrome
Neuropeptide Y
