摘要
以乙酰乙酸乙酯和2,6-二氯-4-三氟甲基苯肼为原料,制得3-甲基-1-(2,6-二氯-4-三氟甲基)苯基-5-吡唑啉酮,产率76%;以上述产物为原料,与取代酰氯反应合成3-甲基-1-(2,6-二氯-4-三氟甲基)苯基-4-苯酰基-5-吡唑啉酮。产物经红外光谱、核磁共振谱等确认结构。此法后处理简单,操作安全。合成的含三氟甲基的5-吡唑啉酮类衍生物,为开发新型含氟吡唑杂环化合物奠定了基础。
3-Methyl-1-（2,6-dichloro-4-trifluoromethyl） phenyl-5-pyrazolone was synthesized with the yield of76% with ethyl acetoacetate and 2,6-dichloro-trifluoromethyl phenyl hydrazine as the materials,and3-methyl-1-（2,6-dichloro-4-trifluoromethyl） phenyl-4-benzoyl-5-pyrazolone was synthesized with the above product and substituted acyl chloride as the materials.The structures of the two products were confirmed via infra-red spectra technique and nuclear magnetic resonance spectra technique,etc.This method is characterized by simple after-treatment and safe operation.It can be used to synthesize trifluoromethyl containing 5-pyrazolone derivatives.It lays the foundation for the development of new fluoro-pyrazole containing heterocyclic compounds.
作者
李术艳
沈淑君
LI Shuyan SHEN Shujun(Department of Food and Biology Engineering, Zhangzhou Institute of Technology, Zhangzhou, Fujian 363000 Applied Technology and Engineering Center of Agriculture Products Further Processing and Safety, Higher Education Institution of Fujian Province, Zhangzhou, Fujian 363000)
出处
《精细石油化工进展》
CAS
2017年第1期55-57,共3页
Advances in Fine Petrochemicals
基金
福建省教育厅科技计划项目(JA13388)
漳州职业技术学院科研项目(ZZY1308)
