摘要
目的探究胎儿畸形筛查中B超测量颈项透明层(NT)值的作用。方法回顾性分析269例定期行产前检查的高危胎儿畸形的孕产妇的临床资料,均于孕11~13周采用B超行NT值检测,关于染色体、引产、分娩或尸检结果均详细记录。评估孕早期B超测量NT值对胎儿畸形诊断的准确度、敏感度和特异度。绘制受试者工作特征曲线(ROC),以曲线下面积(AUC)评估B超测量NT值在胎儿畸形筛查中的作用。结果 269例高危胎儿畸形孕产妇中共确诊20例胎儿畸形,胎儿畸形发生率为7.43%;未发现畸形的胎儿中,B超测量NT>2.5 mm者共有13例,NT≤2.5 mm者共有236例;畸形的胎儿中,B超测量NT>2.5 mm者共有15例,NT≤2.5 mm者共有5例;B超测量NT值在胎儿畸形诊断中的AUC为0.926,且不同NT值条件下对胎儿畸形筛查的灵敏度、特异度、准确度均比较高。结论胎儿畸形筛查中B超测量NT值准确性较高,值得在孕11~13周妇女中推广应用。
Objective To explore the effect of nuchal translucency （NT） thickness measurement by type B uhrasound in screening of fetal malformations. Methods The clinical data of two hundred and sixty-nine pregnant women with high-risk fetal malformations detected during regular prenatal care in the hospital were retrospectively analyzed, NT thickness was measured by type B ultrasound during 11-13 gestational weeks, chromosomes, induced labor, delivery or autopsy results were recorded in detail. The accuracy, sensitivity and specificity of NT thickness measurement by type B ultrasound during early pregnancy were evaluated. Receiver operating characteristic （ROC） curve was drawn to assess the effect of NT thickness measurement by type B ultrasound in screening of fetal malformations by measuring the area under the curve （AUC） . Results Among 269 pregnant women with high-risk fetal malformations, 20 cases of fetal malformations were diagnosed definitely, the incidence rate of fetal malformations was 7.43%. Among the cases without fetal malformations, 13 cases were found with NT thickness〉2. 5 mm, and 236 cases were found with NT thickness ≤ 2. 5 mm. Among the cases with fetal malformations, 15 cases were found with NT thickness〉2. 5 mm, and 5 cases were found with NT thickness≤2. 5 mm. AUC of NT thickness measurement by type B ultrasound in screening of fetal malformations was 0. 926, the sensitivities, specificities and accuracies of fetal malformations screening were high under different NT thicknesses. Conclusion The accuracy of NT thickness measurement by type B ultrasound in screening of fetal malformations is high, which is worthy of popularization and application among the pregnant women during 11-13 gestational weeks.
作者
秦晓娜
QIN Xiao-Na.(Department of Ultrasound, Liaoning Provincial Maternal and Child Health Care Hospital, Shenyang, Liaoning 110005, China)
出处
《中国妇幼保健》
CAS
2017年第5期1077-1079,共3页
Maternal and Child Health Care of China
关键词
胎儿
畸形筛查
B超
颈项透明层
诊断价值
Fetus
Malformation screening
Type B ultrasound
Nuchal translucency
Diagnostic value
