摘要
人类基因组8%是由逆转录病毒基因组成。人内源性逆转录病毒(human endogenous retrovirus,HERV)是外源性逆转录病毒感染人类并整合到人类基因组中,以孟德尔遗传定律遗传下来的残余物。其中HERV-K是HERV中最完整的具有开放阅读框的病毒家族,与白血病等肿瘤的发生发展相关。本文将介绍HERV-K与白血病发生之间的关系。
8% content of human genome is made up of retroviral genes.Human endogenous retrovirus（HERV） is a group of nucleotide sequences generated from exogenous retrovirus by infecting humans and subsequently integrating into the human genome,which is inherited from Mendel＇s genetic law.Among them,HERV-K is the most complete virus family with open reading frame in HERV,which is related to the occurrence and development of leukemia and other tumors.This article will introduce the relationship between HERV-K and leukemia.
出处
《现代肿瘤医学》
CAS
2017年第8期1315-1318,共4页
Journal of Modern Oncology
基金
国家自然科学基金面上项目(编号:81270597)
武汉大学校级大学生创新创业训练项目(编号:S2016884)
