摘要
目的探讨白细胞介素-32(interleukin-32,IL-32)、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)在类风湿性关节炎(rheumatoid arthritis,RA)诊断和预后观察中的价值。方法选取115例RA患者和76例对照组患者,采用ELISA法检测血清中IL-32水平,并通过免疫比浊法测定hs-CRP。结果 RA组与对照组比较,血清IL-32、hs-CRP水平显著升高(P<0.01),活动期组高于缓解期组(P<0.05),RA重度活动期组高于轻度活动期组(P<0.05),均有统计学意义,不同X线分期中,Ⅳ期RA患者血清IL-32和hs-CRP比Ⅰ期均升高(P均<0.01)。结论 IL-32、hs-CRP与RA的形成、病程发展密切相关,可作为判断RA病情严重和骨质破坏程度的重要指标,联合检测对RA诊断及疗效观察有重要意义。
Objective To investigate the significance of interleukin-32（IL-32）,and hypersensitive C-reactive protein（hs- CRP） in rheumatoid arthritis（RA）. Methods IL- 32 was detected by ELISA and hs- CRP was measured byimmunoturbidimetric assay in 115 cases of rheumatoid arthritis and 76 healthy controls. Results The levels of IL-32 and hs-CRP of the RA group were significantly higher than those of the healthy control group（P〈0.01）,and the levels of IL-32 and hs-CRP of the RA active subgroup were significantly higher than those of the stable subgroup（P〈0.05）. In addition,among thedifferent joint X-ray stages,the levels of IL-32 and hs-CRP of the Stage Ⅳ subgroup were significantly higher than those ofthe Stage Ⅰ subgroup（P〈0.01）. Conclusion IL-32 and hs-CRP are correlated with the pathogenesis and activity of RA,which could be used as important serum markers for clinical activity and therapeutic effect of RA patients.
出处
《中国热带医学》
CAS
2017年第2期188-189,192,共3页
China Tropical Medicine
